NPM1 / Nucleophosmin抗体

NPM1 / Nucleophosmin抗体产品信息

免疫原 :
Recombinant NPM1 / Nucleophosmin protein (Catalog#10053-H07E)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, recombinant NPM1 / Nucleophosmin (rh NPM1 / Nucleophosmin; Catalog#10053-H07E; P06748-1; Met 9-Leu 158). NPM1 / Nucleophosmin specific IgG was purified by NPM1 / Nucleophosmin affinity chromatography.
NPM1 / Nucleophosmin抗体Background
Nucleophosmin, also known as Nucleolar phosphoprotein B23, Nucleolar protein NO38, Numatrin and NPM1, is a nucleus protein which belongs to thenucleoplasmin family. Nucleophosmin / NPM1 is a nucleolar phosphoprotein that shuttles between the nucleus and cytoplasm during the cell cycle. Nucleophosmin / NPM1 is involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors TP53 / p53 and ARF. Subcellular localization of Nucleophosmin / NPM1 appears to be strongly correlated with NPM1 functions and cell proliferation. It is phosphorylated mainly at its central acidic domain by several upstream kinases, and its phosphorylation appears to be involved in regulating its functions in ribosome biogenesis and centrosome duplication. Nucleophosmin / NPM1 binds ribosome presumably to drive ribosome nuclear export. It is associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Nucleophosmin / NPM1 acts as a chaperonin for the core histones H3, H2B and H4. Nucleophosmin / NPM1 may act as a licensing factor to maintain proper centrosome duplication and that the Ran/CRM1 nucleocytoplasmic complex regulates local trafficking of Nucleophosmin / NPM1 to centrosomes by interacting through its nuclear export sequence motif.
NPM1 / Nucleophosmin抗体相关产品如下：
hzR-0370hz Goat IgM/RBITC罗丹明标记羊IgM
hzR-0358hz Guinea IgG/RBITC罗丹明标记豚鼠IgG
hzR-0375hz Guinea IgM/RBITC罗丹明标记豚鼠IgM
hzR-0308hz Horse IgG/RBITC罗丹明标记马IgG
hzR-0374hz Horse IgM/RBITC罗丹明标记马IgM
hzR-0297hz human IgG/RBITC罗丹明标记人IgG
hzR-0345hz human IgM/RBITC罗丹明标记人IgM
hzR-0360hz human IgA/RBITC罗丹明标记人IgA
hzR-0335hz Monkey IgG/RBITC罗丹明标记猴IgG
hzR-0336hz Monkey IgM/RBITC罗丹明标记猴IgM
hzR-0368hz Mouse IgM/RBITC罗丹明标记小鼠IgM
hzR-0309hz pig IgG/RBITC罗丹明标记猪IgG
hzR-0777hz Mink IgG/RBITC罗丹明标记水貂IgG
hzR-0369hz Rabbit IgM/RBITC罗丹明标记兔IgM
hzR-0346hz Rat IgM/RBITC罗丹明标记大鼠IgM
hzR-0884hz rHIL-1Ra/RBITC罗丹明标记重组人白介素-1受体拮抗剂
hzR-0789hz Insulin Protein/RBITC罗丹明标记猪胰岛素蛋白
hzR-hz0002 KLH/RBITC罗丹明标记血蓝蛋白
hz-0283hz-RBIThz OVA/RBITC罗丹明标记鸡卵白蛋白
hzR-2179hz AACT/RBITC罗丹明标记胰糜蛋白酶
hzF-0789hzH Insulin Protein/FITC荧光素标记人胰岛素蛋白
hzGA-0360G Goat Anti-human IgA/Gold金标记羊抗人IgA(10nm/15nm)
hzGA-0360R Rabbit Anti-human IgA/Gold金标记兔抗人IgA(10nm/15nm)
hzGA-0356R Rabbit Anti-digoxin/Gold金标记兔抗 (10nm/15nm)
hzGA-0312hz Avidin/Gold金标记亲合素(10nm/15nm)
hzGA-0362hz Protein A/Gold金标记蛋白A(10nm/15nm)
hz-0360G Goat Anti-human IgA羊抗人免疫球蛋白A
hzA-8 Rabbit Anti-human k-chain兔抗人k-链（亲和层析纯化）