VEGFR3 / FLT4 抗体

VEGFR3 / FLT4 抗体产品信息

免疫原 :
Recombinant human VEGFR3 protein ( Catalog#10806-H08H )
克隆号 :
2B2F12C5
抗体宿主 :
Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human VEGFR3 extracellular domain ( rhVEGFR3; Catalog#10806-H08H; aa 1 - 776; NP_002011.2 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
VEGFR3 / FLT4 抗体背景综述
VEGFR3 (FLT4), together with the other two members VEGFR1 (FIT1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs). VEGFR3 is widely expressed in the early embryo but becomes restricted to lymphatic endothelia at later stages of development. Upon ligand binding, VEGFR3 become activated through transphosphorylation after homodimerization and subsequently interacts with the adaptor proteins such as SHC and GRB2, and thus mediates the cellular responses of VEGF. Both VEGF-C and VEGF-D have been identified as ligands for VEGFR3. The VEGF receptors are essential for vasculogenesis and angiogenesis, while VEGFR3 plays a significant role in ligand mediated lymphangiogenesis. Mutation in its gene is associated with the primary lymphedema which is a rare genetic condition with both autosomal dominant and autosomal recessive modes of inheritance.
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