SIGNR1 / CD209b抗体

SIGNR1 / CD209b抗体产品信息

免疫原 :
Recombinant Mouse SIGNR1 / CD209b protein (Catalog#50486-M07H)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, recombinant Mouse SIGNR1 / CD209b (rM SIGNR1 / CD209b; Catalog#50486-M07H; NP_081248.2; Gln 74-Gly 325). SIGNR1 / CD209b specific IgG was purified by Mouse SIGNR1 / CD209b affinity chromatography.
SIGNR1 / CD209b抗体Background
CD209 antigen-like protein B, also known as DC-SIGN-related protein 1, DC-SIGNR1 and Cd209b, is a a single-pass type II membrane protein which contains oneC-type lectin domain. CD209B is expressed in skin, spleen and lung, probably in a subset of dendritic cells. It is detected in spleen extrafollicular paracortical areas including the red pulp and marginal zones, and at lower levels, in the follicular area. It is also detected in skin suprabasal areas adjacent to the epidermis and in epidermal cell layer. CD209B is a pathogen-recognition receptor. It may mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. CD209B may recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. It is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. In vitro, CD209B is a receptor for HIV-1, HIV-2 and SIV, but does not transmit virus to permissive T-cells under the conditions tested.
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