Contactin 1 / CNTN1抗体

Contactin 1 / CNTN1抗体产品信息

免疫原 :
Recombinant Human Contactin 1 / CNTN1 protein (Catalog#10383-H08H)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, recombinant Human Contactin 1 / CNTN1 (rHuman Contactin 1 / CNTN1; Catalog#10383-H08H; NP_001834.2; Met 1-993). Contactin 1 / CNTN1 specific IgG was purified by Human Contactin 1 / CNTN1 affinity chromatography.
Contactin 1 / CNTN1抗体Background
Contactin-1 (CNTN1) is a member of the contactin sbufamily belonging to immunoglobulin superfamily. CNTN1 is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein consisting of 4 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains, and is expressed in numerous neuronal tissues, as well as neuroblastoma and retinoblastoma cell lines. As a cell adhesion molecule, CNTN1 plays a role in the formation of axon connections in the developing nervous system. It was demonstrated that CNTN1 participates in signal pathways via its association with Contactin-associated protein (CNTNAP1), receptor protein tyrosine phosphatase beta (RPTPb) and NOTCH1, and thus is involved in paranodal axo-glial junction formation and oligodendrocytes generation. Furthermore, studies indicated that CNTN1 functions importantly in the invasion and metastasis of lung adenocarcinoma cells.
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