Contactin-1 / CNTN1抗体

Contactin-1 / CNTN1抗体产品信息

免疫原 :
Recombinant human CNTN1 protein ( Catalog#10383-H08H )
抗体类型: Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
10B3B1D1
抗体宿主 : Mouse IgG2b
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human CNTN1 ( rhCNTN1; Catalog#10383-H08H; aa 1- 993; NP_001834.2 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Contactin-1 / CNTN1抗体背景综述
Human contactin-1 (CNTN1) is a member of the contactin sbufamily belonging to immunoglobulin superfamily. CNTN1 is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein and is expressed in numerous neuronal tissues, as well as neuroblastoma and retinoblastoma cell lines. As a cell adhesion molecule, CNTN1 plays a role in the formation of axon connections in the developing nervous system. It was demonstrated that CNTN1 participates in signal pathways via its association with Contactin-associated protein (CNTNAP1), receptor protein tyrosine phosphatase beta (RPTPb) and NOTCH1, and is involved in paranodal axo-glial junction formation and oligodendrocytes generation. Furthermore, studies indicated that CNTN1 functions importantly in the invasion and metastasis of lung adenocarcinoma cells.
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