CD32a / Fc gamma RIIA / FCGR2A

CD32a / Fc gamma RIIA / FCGR2A抗体产品信息

免疫原 :
Recombinant Cynomolgus CD32a / Fc gamma RIIA / FCGR2A protein (Catalog#90016-C08H)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, recombinant Cynomolgus CD32a / Fc gamma RIIA / FCGR2A (rC CD32a / Fc gamma RIIA / FCGR2A; Catalog#90016-C08H; Met 1-Ile 217). CD32a / Fc gamma RIIA / FCGR2A specific IgG was purified by Cynomolgus CD32a / Fc gamma RIIA / FCGR2A affinity chromatography.
CD32a / Fc gamma RIIA / FCGR2A抗体 Background
Receptors that recognize the Fc portion of IgG (Fcγ Rs) functions in the regulation of immune response and are divided into three classes designated Fcγ RI (CD64), Fcγ RII (CD32), and Fcγ RIII (CD16). Fcγ RI binds IgG with high affinity and functions during early immune responses, whereas Fcγ RII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses. Low affinity immunoglobulin gamma Fc region receptor II-a, also known as IgG Fc receptor II-a, Fc-gamma-RIIa, CD32a and FCGR2A, is a single-pass type I membrane protein which contains twoIg-like C2-type (immunoglobulin-like) domains. CD32a / FCGR2A is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. Associated with an ITAM (immunoreceptor tyrosine-based activation motif)- bearing adapter subunit, FcRγ, CD32a / FCGR2A delivers an activating signal upon ligand binding, and results in the initiation of inflammatory responses including cytolysis, phagocytosis, degranulation and cytokine production. The responses can be modulated by signals from the coexpressed inhibitory receptors such as FcγRIIB, and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.
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