CD16a / FCGR3A / FcRIIIa抗体

CD16a / FCGR3A / FcRIIIa抗体产品信息

Immunogen:
Recombinant human CD16a protein ( Catalog #10389-H08H )
Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
Clone ID:
5B7F4D5
Ig Type: Mouse IgG1
缓冲液: 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
Preparation:
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human CD16a ( rhCD16a ; Catalog#10389-H08H ; NP_001121068.1 ; Met 1- Gln 208 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
CD16a / FCGR3A / FcRIIIa抗体 Background
CD16 (Fcγ RIII) is a multifunctional,low/intermediate affinity receptor. In human, CD16 is expressed as two distinct forms (CD16a and CD16b) encoded by two different highly homologous genes in a cell type-specific manner. CD16a is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed by a subset of T lymphocytes, natural killer (NK) cells, monocytes, and macrophages. CD16a has an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and delivers an activation signal in the immune responses. As an inflammatory mediator, CD16a receptor is involved in phagocytosis, secretion of enzymes, antibody-dependent cellular cytotoxicity(ADCC), mast cell degranulation, and clearance of immune complexes.
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