PLAUR / CD87 / uPAR抗体

PLAUR / CD87 / uPAR抗体产品信息

免疫原 :
Recombinant Human PLAUR / CD87 / uPAR protein (Catalog#10925-H08H)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, recombinant Human PLAUR / CD87 / uPAR (rh PLAUR / CD87 / uPAR; Catalog#10925-H08H; Q03405-1; Met 1-Arg 303). PLAUR / CD87 / uPAR specific IgG was purified by Human PLAUR / CD87 / uPAR affinity chromatography.
PLAUR / CD87 / uPAR抗体Background
Urokinase type plasminogen activator (uPA) receptor (uPAR) binds uPA and pro-uPA with high affinity and allows bound uPA to activate plasminogen. uPAR / CD87 is a highly glycosylated, 55-60kDa integral membrane protein linked to the plasma membrane by a glycosylphosphatidylinositol (GPI) anchor. uPAR / CD87 plays a critical role in the regulation of cell-surface plasminogen activation in physiological and pathological conditions, and it is also involved in cellular adhesion, the transmission of extracellular signals across the plasma membrane and the subsequent regulation of gene expression. The uPAR / CD87 has been implicated in several biological processes including angiogenesis, monocyte migration, cancer metastasis, trophoblast implantation, and wound healing. The human uPAR / CD87 shows 60-70% similarity with the murine uPAR amino acid sequence although binding of uPA to uPAR shows strong species specificity.
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