ENTPD3 / NTPDase3 / CD39L3抗体

ENTPD3 / NTPDase3 / CD39L3抗体产品信息

免疫原 :
Recombinant Human ENTPD3 / NTPDase3 / CD39L3 protein (Catalog#10909-H08B)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, recombinant Human ENTPD3 / NTPDase3 / CD39L3 (rh ENTPD3 / NTPDase3 / CD39L3; Catalog#10909-H08B; O75355; Gln44-Pro485). Total IgG was purified by Protein A affinity chromatography.
ENTPD3 / NTPDase3 / CD39L3抗体 Background
Ectonucleoside triphosphate diphosphohydrolase 3, also known as ENTPD3, NTPDase3, and CD39L3, is an integral membrane glycoprotein. ENTPD3 is similar to E-type nucleotidases (NTPases). NTPasea, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD3 contains 4 apyrase-conserved regions which is characteristic of NTPases. It has been reported that the obstructive disease cystic fibrosis (CF) affects the activity, expression, and tissue distribution of two ectonucleotidase found critical for the regulation of ATP on airway surfaces : NTPDase1 and NTPDase3. High densities of NTPDase3 positive terminals were associated with noradrenergic neurons. Semi-quantitative immunohistochemistry revealed increased NTPDase3 immunolabelling in the synaptic regions of the inner and outer hair cells at sound intensities that induce temporary threshold shift which suggest a role for NTPDase3 in regulating ATP signaling associated primarily with auditory neurotransmission, and the potential neuroprotective nature of noise-induced up-regulation of this extonucleotidase in the cochlea.
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