转录本基因功能研究:崭新的基因功能研究机会

研究案例-MAT2B：

Aliases	Descriptions
MAT-II 2	DTDP-4-keto-6-deoxy-D-glucose 4-reductase 2, 3
MATIIbeta 1, 2	MAT II beta 3
MGC12237 2	Methionine adenosyltransferase 2 beta subunit 3
Nbla02999 2	Methionine adenosyltransferase II beta 3
TGR 2, 3	beta regulatory subunit of methionine adenosyltransferase 2

External Ids

HGNC: 69051

Entrez Gene: 274302

UniProt: Q9NZL93

Ensembl: ENSG000000382747

Summary:
The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq]

Function:

Non-catalytic regulatory subunit of S-adenosylmethionine synthetase 2(MAT2A), an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates the activity of S-adenosylmethionine synthetase 2 by changing its kinetic properties, rendering the enzyme more susceptible to S-adenosylmethionine inhibition

REFSEQ proteins (2 alternative transcripts):

NP_037415.1
NP_877725.1

转录本研究成果：IF=12.4


转录本现象在自然界普遍存在，但是，至今没有很好的方法进行深入的研究，直到RNAI和回复实验相结合：
可以实现的转录本研究的候选基因请致电吉凯基因查询。

RNAI干扰回复实验技术说明：

RNAI干扰回复实验技术说明：

Blastp:

Blast结论：

转录本基因功能研究：崭新的基因功能研究机会


MAT2B的两个转录本仅在一端有差异





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