bFGF / FGF2抗体

bFGF / FGF2抗体产品信息

免疫原 :
Recombinant human bFGF protein ( Catalog #10014-HNAE )
抗体类型: Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 :
101
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was obtained from a rabbit immunized with purified, E.coli-derived, recombinant human bFGF / FGF2 ( rh FGF2; Catalog#10014-HNAE; NP_001997.5; Pro 143 - Ser 288 ).
bFGF / FGF2抗体背景综述
bFGF (FGF basic) is a member of the FGF family consisting of at least 23 related mitogenic proteins and is secreted by mechanisms other than the classical protein secretion pathway due to the lack of signal peptide. bFGF is expressed extensively, including neural tissue, pituitary, adrenal cortex, corpus luteum, and placenta. Members of the fibroblast growth factor (FGF) family of proteins stimulate the proliferation and differentiation of target cells through receptor-mediated pathways, and it appears that FGF acidic and basic bind to the same high affinity receptors. Binding of bFGF to heparin or cell surface heparan sulfate proteoglycans is prerequisite for ligation of bFGF and the high affinity receptors. FGF basic and acidic have a similar range of biological activities which are implicated in several important physiological and pathological processes, such as embryonic development and differentiation, morphogenesis, angiogenesis, and wound healing. Five different isoforms with distinct properties are resulted from alternative translation from non-AUG (CUG) and AUG initiation codons. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.
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