CNTNAP2 / CASPR2抗体

CNTNAP2 / CASPR2抗体产品信息

免疫原 :
Recombinant Mouse CNTNAP2 / CASPR2 protein (Catalog#50649-M08H)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, recombinant Mouse CNTNAP2 / CASPR2 (rM CNTNAP2 / CASPR2; Catalog#50649-M08H; NP_001004357.2; Met 1-Ser 1262). CNTNAP2 / CASPR2 specific IgG was purified by Mouse CNTNAP2 / CASPR2 affinity chromatography.
CNTNAP2 / CASPR2抗体Background
Contactin-associated protein-like 2, also known as Cell recognition molecule Caspr2, CNTNAP2 and CASPR2, is a single-pass type I membrane protein which belongs to the neurexin family. CNTNAP2 contains two EGF-like domains, one F5/8 type C domain, one fibrinogen C-terminal domain, fourlaminin G-like domains. Defects in CNTNAP2 are the cause of cortical dysplasia-focal epilepsy syndrome (CDFES). Affected individuals manifest cortical dysplasia, focal epilepsy, relative macrocephaly, and diminished deep-tendon reflexes. Intractable focal seizures begin in early childhood, after which language regression, hyperactivity, impulsive and aggressive behavior, and mental retardation develop. Genetic variations in CNTNAP2 influences susceptibility to autism type 15 which is a neurodevelopmental disorder characterized by disturbance in language, perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypical, and ritualized patterns of interests and behavior.
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