NTRK1 / Trk-A / TRKA抗体

NTRK1 / Trk-A / TRKA抗体产品信息

免疫原 :
Recombinant human NTRK1 protein ( Catalog#11073-H08H )
抗体类型: Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
9D6B4B3
抗体宿主 :
Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human NTRK1 / Trk-A ( rh NTRK1 ; Catalog#11073-H08H ; NP_002520.2 ; Met 1- Pro 382 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography
NTRK1 / Trk-A / TRKA抗体背景综述
Neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), also well known as Trk-A, is a member of the neurotrophic tyrosine kinase receptor family belonging to Tyr protein kinase superfamily, which also includes Trk-B and Trk-C. Trk-A has a complex subdomain orgnazation conserved in the family members, containing two cysteine-rich domains, a cluster of three leucine-rich motifs (LRR), and two Ig-like C2-type domains in the extracellular region, as well as an tyrosine kinase domain in the cytoplasmic region. Trk-A exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures, and is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Trk A plays an important role in cell survival, differentiation, and apoptosis in various neuronal and nonneuronal cell types, especially in the nervous system by recruiting signaling molecules including SHC1, PI 3-kinase, and PLC-gamma-1 that activate pathways required for the growth and survival of neurons. It has been shown that TrkA is specially involved in the development and function of the nociceptive reception system and establishment of thermal regulation via sweating. Two distinct Trk-A isoforms have been identified: TrkA-II is primarily expressed in neuronal cells, while isoform TrkA-I is found in non-neuronal tissues. Defects in NTRK1 are a cause of a rare autosomal recessive disorder, congenital insensitivity to pain with anhidrosis (CIPA).
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