MSR1 / SCARA1 / CD204抗体

MSR1 / SCARA1 / CD204抗体产品信息

免疫原 :
Recombinant human MSR1 protein ( Catalog#10427-H07H )
Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
4E5C10B1
抗体宿主 :
Mouse IgG2b
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human MSR1 ( rh MSR1 ; Catalog#10427-H07H ; NP_619729.1 ; Lys 77 - Leu 451 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
MSR1 / SCARA1 / CD204抗体背景综述
Scavenger receptors are a group of membrane receptors that recognize and internalize modified low density lipoproteins (LDLs) and participate in the removal of many foreign substances and waste materials in the living body. Scavenger receptors are categorized into three classes, and class A mainly expressed in macrophage includes three isoforms derived by alternative splicing. The class A macrophage scavenger receptor are trimers with a molecular weight of about 220-250 kDa, and isoformⅠ( SR-AI or MSR-AI ) contains six predicted structural domains: cytoplasmic, transmembrane, spacer, α-helical coiled coil, collagenous, and an isoform-specific cysteine-rich C-terminus which are truncated in SR-AII and SR-AIII. SR-AI /II are functional receptors and are able to mediate the endocytosis of low density lipoproteins (LDLs) modified by oxidation or acetylation., nucleic acids, and a variety of plant and microbial cell wall constituents, whereas SR-A III is trapped in the endoplasmic reticulum and acts as a dominant negative protein with respect to SR-A activity. Accordingly, SR-A has been implicated in the development of atherosclerotic lesions and other macrophage-associated host defense reponses. Also, SR-A has been suggested to play important roles in macrophage growth, cell adhesion, osteoclast differentiation, and as well as intracellular signaling.
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