CHL-1抗体

CHL-1抗体产品信息

免疫原 :
Recombinant Human CHL-1 Protein (Catalog#10143-H08H)
Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
6E6E4
抗体宿主 :
Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant Human CHL-1 (rhCHL-1; Catalog#10143-H08H; NP_006605.2 ; Met 1 - Gln 1080). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
CHL-1抗体Background
Neural cell adhesion molecule L1-like protein, also known as Cell adhesion molecule with homology to L1CAM, Close homolog of L1, Chl1-like protein, Chl1 and Call, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and L1 / neurofascin / NgCAM family. CHL1 / CALL is expressed in the brain, in the cerebellum and in the spinal cord. It is detected in the retina and the optic nerve. It is also expressed in neurons and glial cells in the central nervous system and by schwann cells in the peripheral nervous system. CHL1 / CALL is an extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. CHL1 / CALL plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. CHL1 / CALL may play a role in regulating cell migration in nerve regeneration and cortical development.
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