CD44 Antibody

CD44 Antibody Product Information

Immunogen :
Recombinant Human CD44 protein (Catalog#12211-H08H)
Reagents : PE-conjugated mouse monoclonal antibody
Clone ID :
9G5B5
Ig Type :
Mouse IgG1
Concentration :
1 μl/Test, 0.1 mg/ml
Formulation : Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD44 (rh CD44; Catalog#12211-H08H; P16070-1; Met 1-Pro 220) and conjugated with PE under optimum conditions, the unreacted PE was removed.
CD44 AntibodyBackground
CD44, short for Cluster of Differentiation 44, is an adhesion molecule of the hyaluronate receptor family. It is expressed in a large number of mammalian cell types. The adhesive function of CD44, like other molecules involved in inducible adhesion, is tightly regulated. Post-translational modifications, isoform expression, aggregation state, and protein associations all can affect the ligand binding properties of CD44, and these can vary depending on the cell type and the activation state of the cell. The principal ligand of CD44 is hyaluronan, and CD44 is involved in the metabolism of this compound. Furthermore, an increasing quantity of evidence suggests that CD44 has various functions related to inflammatory disease. CD44 deficiency induces severe liver injury. CD44-hyaluronate mediates in lymphocyte T and monocyte adhesion to the endothelium, stimulates proinflammatory cytokine release from macrophages and participates in dedifferentiation phenotype of smooth muscle cells from contractile state to synthetic one. CD44 acts in atherosclerotic plaque destabilization and neointimal proliferation after percutaneous vascular interventions. CD44 participates in many stages of atherosclerosis. CD44 also is a cell membrane protein often overexpressed on tumor cells and, being both a cell-cell and cell-extracellular matrix adhesion protein, is well positioned to contribute to this process.
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