IL18 / Interleukin-18抗体

IL18 / Interleukin-18抗体产品信息

免疫原 :
Recombinant Cynomolgus IL18 / Interleukin-18 Protein (Catalog #90011-C07E)
Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
5G10E10
抗体宿主 :
Mouse IgG2a
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant Cynomolgus IL18 / Interleukin-18 (rC IL18 / Interleukin-18; Catalog #90011-C07E; Ala 2-Asp 193). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
IL18 / Interleukin-18抗体Background
Interleukin-18, also known as Interferon gamma-inducing factor, Iboctadekin, IFN-gamma-inducing factor, Interleukin-1 gamma, IL-1 gamma IL1F4 and IL18, is a secreted protein which belongs to the IL-1 family. IL-18 / Interleukin-18 is related to the IL1 family by structure, receptors, signalling molecules, and function. IL18 induces gene expression and synthesis of tumour necrosis factor (TNF), IL1, Fas ligand, several chemokines, and vascular adhesion molecules. Similar to IL-1beta, IL-18 / Interleukin-18 is synthesised as a biologically inactive precursor molecule lacking a signal peptide. IL-18 / Interleukin-18 augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. Rheumatoid arthritis (RA) is a complex autoimmune disease with a strong genetic contribution to its pathogenesis. Interleukin-18 (IL-18) is a proinflammatory cytokine involved in the pathogenesis of RA. IL-18 / Interleukin-18 is also a proinflammatory cytokine whose levels are increased in the subclinical stage of insulin-dependent (type I) diabetes mellitus.
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