H7N7 HA / Hemagglutinin Antibody Product Information
Immunogen :
Recombinant H7N7 HA protein
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
Clone ID :
19
Ig Type :
Rabbit IgG
Formulation : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
Preparation :
This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant influenza A H7N7 HA / Hemagglutinin protein
H7N7 HA / Hemagglutinin Antibody Background
Hemagglutinin (HA) is a single-pass type I integral membrane glycoprotein from the influenza virus, and comprises over 80% of the envelope proteins present in the virus particle. In natural infection, inactive HA is matured into HA1 and HA2 outside the cell by one or more trypsin-like, arginine-specific endoprotease secreted by the bronchial epithelial cells. Binding of HA to sialic acid-containing receptors on the surface of its target cell brings about the attachment of the virus particle to the cell and forms a endosome. Low pH in endosomes induce an irreversible conformational change in HA2, releasing the hydrophobic portion “fusion peptide”. After which, virus penetrates the cell and pours its contents including the RNA genome into the cytoplasm mediated by fusion of the endocytosed virus particle’s own membrane and the endosomal membrane.
H7N7 is a subtype of Influenza virus A. It can infect humans, birds, pigs, seals, and horses in the wild and has infected mice in laboratory studies. H7N7 represents a pandemic threat because influenza H7N7 viruses do not commonly infect humans, there is little or no antibody protection against these viruses in the human population. If an avian or other animal influenza virus of H7N7 is able to infect people, cause illness, and spread efficiently from person to person, an influenza pandemic could begin. In 2003 in the Netherlands 89 people were confirmed to have the H7N7 influenza virus infection following an outbreak in poultry on several farms. One death was recorded. Antibodies were found in over half of 500 people tested according to the final official report by the Dutch government. Final analysis of Dutch avian influenza outbreaks reveals much higher levels of transmission to humans than previously thought.
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