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- 2025年07月10日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
常温，避光
- 克隆性：
单克隆
- 抗体名：
IL18 / Interleukin-18抗体
Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 : 5G10E10
抗体宿主 : Mouse IgG2a
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant Cynomolgus IL18 / Interleukin-18 (rC IL18 / Interleukin-18; Catalog #90011-C07E; Ala 2-Asp 193). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
IL18 / Interleukin-18抗体 Background
Interleukin-18, also known as Interferon gamma-inducing factor, Iboctadekin, IFN-gamma-inducing factor, Interleukin-1 gamma, IL-1 gamma IL1F4 and IL18, is a secreted protein which belongs to the IL-1 family. IL-18 / Interleukin-18 is related to the IL1 family by structure, receptors, signalling molecules, and function. IL18 induces gene expression and synthesis of tumour necrosis factor (TNF), IL1, Fas ligand, several chemokines, and vascular adhesion molecules. Similar to IL-1beta, IL-18 / Interleukin-18 is synthesised as a biologically inactive precursor molecule lacking a signal peptide. IL-18 / Interleukin-18 augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. Rheumatoid arthritis (RA) is a complex autoimmune disease with a strong genetic contribution to its pathogenesis. Interleukin-18 (IL-18) is a proinflammatory cytokine involved in the pathogenesis of RA. IL-18 / Interleukin-18 is also a proinflammatory cytokine whose levels are increased in the subclinical stage of insulin-dependent (type I) diabetes mellitus.
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文献和实验相关专题 &NBS p; Interleukin 18 (interferon-gamma-inducing factor) IL-18 is a cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other Cell s. IL-18 works by binding
-Class (D200-domain) Cytokine Receptor Activity (19): CSF2RB, CSF3R, IFNAR2, IL10RA, IL10RB, IL12B, IL12RB1, IL12RB2, IL13RA1, IL20RA, IL2RB, IL3RA, IL4R, IL5RA, IL6R, IL6ST, IL7R, IL9R, LIFR. Interleukin Receptors (8): IL12RB1, IL12RB2, IL15RA, IL18
【进展|热点】Nature：TGF-β并非Th17细胞分化的必要因素
增强，被TGF-β1削弱。在没有TGF-β1的情况下，IL-1β、IL-6和IL-23促进Th17细胞的分化与其改变IL-17A/F、RORC启动子区域的表观遗传学状态有关。 对这群分化不依赖于TGF-β1的Th17细胞进行表型和功能的分析发现：在表型方面，与传统的Th17细胞（经由IL-1β、IL-6、TGF-β1和IL-23联合作用分化而来）相比，这类Th17细胞CCL9、IL-2、IL-33、IL18R1和CXCR3表达水平较高， IL-19、IL-10、CCL20和CXCR6表达水平较低
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