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- 保存条件：
常温，避光
- 克隆性：
单克隆
- 抗体名：
HPV16 L1抗体
HPV16 L1抗体产品信息
免疫原 :
Recombinant HPV16 L1 virus like particle
Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
01
抗体宿主 :
Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant HPV16 L1 virus like particle. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
HPV16 L1抗体 Background
Papillomaviruses are highly species-specific and can cause squamous epithelial and fibroepithelial tumors in their hosts. Human papillomaviruses (HPVs) are associated with benign and malignant hyperproliferation of cells, with a wide variety of clinical manifestations ranging from condyloma acuminata to cervical carcinoma. HPV infection is the most common sexually transmitted disease. More than 40 HPV types so far identified are known to infect the genital tract. Genital HPVs are divided into `low risk' HPVs such as HPV 6 and 11 and 'high risk' HPV types such as 16, 18, 31, 33, 35, 39, 45 and 52, 58 which are responsible for more than 95% of HPV-induced cervical cancer. Vaccination against these high risk types seems to be the most feasible prevention for cervical cancer. Indeed, clinical trials have shown prophylactic HPV vaccines to be effective against HPV infection, cervical intraepithelial neoplasia (CIN), and genital warts, but protection is type-specific and the currently developed vaccines target only a few types. These vaccines are based on papillomavirus-like particles (VLPs) composed of the major capsid protein, L1. The L1 protein self assembles into VLPs when expressed at high levels in eukaryotic or insect cells. VLPs are composed of 360 copies of L1 protein organized into 72 pentamers, so called capsomeres, to form particles which are immunologically indistinguishable from native virions. Experimentally induced VLP antisera have been shown to be mostly typespecific with respect to neutralization. Minor cross-neutralization has been observed only between closely related HPV types, e.g. HPV6 and 11, HPV18 and 45, or HPV16 and 31. Structure analysis has revealed the presence of several hyper variable loops on the outer surface of the capsid. With a few exceptions, all HPV-neutralizing monoclonal antibodies analyzed so far are type-specific and recognize conformational epitopes within surface-exposed hyper variable loops of the major capsid protein L1.
HPV16 L1抗体相关产品如下：
hz-7015R STK31丝氨酸/苏氨酸蛋白激酶31抗体
hz-4289R 5HT3B receptor5-羟色胺受体3B抗体
hz-6643R SCYL1BP1SCYL结合蛋白1抗体
hz-2959R 5HTR2C5-羟色胺受体2C抗体
hz-3660R srGAP3精神障碍相关GAP蛋白抗体
hz-3633R Synaptopodin突触足蛋白抗体
hz-2205R SLAMF9CD2F-10抗体
hz-4056R SMURF2Smad蛋白E3泛素连接酶2抗体
hz-2299R phospho-STMN2 (Ser50)磷酸化神经生长相关蛋白SCG10抗体
hz-7729R SMC5染色体结构维持蛋白5抗体
hz-7730R SMC6染色体结构维持蛋白6抗体
hz-7727R SMC2染色体结构维持蛋白2抗体
hz-7725R SA2粘结蛋白SA2抗体
hz-7728R SMC4染色体结构维持蛋白4抗体
hz-7724R Nuclear protein stromal antigen 1粘结蛋白SA1抗体
hz-7716R SPC25纺锤体极点构成蛋白25抗体
hz-12348R 5T4滋养层细胞糖蛋白5T4抗体
hz-1657R phospho-STAT1 (Tyr701)磷酸化信号转导与转录激活因子1抗体
hz-1658R phospho-STAT3 (Tyr705)磷酸化信号转导和转录激活因子3抗体
hz-1791R phospho-STAT6 (Tyr641)磷酸化信号转导和转录激活因子6抗体
hz-3525R SIGLEC14唾液酸结合性免疫球蛋白样凝集素14抗体
hz-0089R Secretin receptor分泌素受体抗体
hz-1127R beta Sarcoglycan肌聚多糖-β抗体
hz-3433R Phospho-Syk (Tyr323)磷酸化非受体型酪氨酸蛋白激酶抗体
hz-3434R Phospho-Syk (Tyr525 + Tyr526)磷酸化非受体型酪氨酸蛋白激酶抗体
hz-0645R Rat secretory IgA分泌型免疫球蛋白A抗体
hz-1096R SKP2细胞S期激酶相关蛋白2抗体
hz-0763R Snake poison Protein蛇毒蛋白抗体（中华眼镜蛇）
hz-0495R Selenoprotein W硒蛋白W抗体
hz-0545R SCF干细胞生长因子抗体
hz-0783R SDF1 beta基质细胞衍生因子－1抗体
hz-1121R Sema3A臂板蛋白3A抗体
hz-1122R semaphorin 3F臂板蛋白3F抗体
hz-1123R Sema4C臂板蛋白4C抗体
hz-1128R SGLT1钠-糖共转运载体1抗体
hz-0211R SHANK 1富含脯氨酸突触相关蛋白SHANK1抗体
hz-1175R SHBG性激素结合球蛋白抗体
hz-1129R SHP-1造血细胞磷酸酶抗体
hz-1233R SHP2蛋白酪氨酸磷酸酶2抗体
hz-0496R SLC24A5可溶性载质转运蛋白SLC24A5抗体
hz-2121R SCYLV甘蔗SCYLV抗体
hz-2536R SREBP-2胆固醇调节元件结合蛋白2抗体
hz-2544R SLAMF7SLAMF7抗体
hz-6733R SECTM1分泌和跨膜蛋白1抗体
hz-6732R SDF4基质细胞衍生因子4抗体（钙结合蛋白）
hz-6737R SVH肝癌蛋白剪接变异体蛋白抗体
hz-7011R SDCCAG8结肠癌抗原8抗体
hz-7009R SART3T淋巴细胞识别的鳞状细胞癌SART3抗体
免疫原 :
Recombinant HPV16 L1 virus like particle
Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
01
抗体宿主 :
Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant HPV16 L1 virus like particle. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
HPV16 L1抗体 Background
Papillomaviruses are highly species-specific and can cause squamous epithelial and fibroepithelial tumors in their hosts. Human papillomaviruses (HPVs) are associated with benign and malignant hyperproliferation of cells, with a wide variety of clinical manifestations ranging from condyloma acuminata to cervical carcinoma. HPV infection is the most common sexually transmitted disease. More than 40 HPV types so far identified are known to infect the genital tract. Genital HPVs are divided into `low risk' HPVs such as HPV 6 and 11 and 'high risk' HPV types such as 16, 18, 31, 33, 35, 39, 45 and 52, 58 which are responsible for more than 95% of HPV-induced cervical cancer. Vaccination against these high risk types seems to be the most feasible prevention for cervical cancer. Indeed, clinical trials have shown prophylactic HPV vaccines to be effective against HPV infection, cervical intraepithelial neoplasia (CIN), and genital warts, but protection is type-specific and the currently developed vaccines target only a few types. These vaccines are based on papillomavirus-like particles (VLPs) composed of the major capsid protein, L1. The L1 protein self assembles into VLPs when expressed at high levels in eukaryotic or insect cells. VLPs are composed of 360 copies of L1 protein organized into 72 pentamers, so called capsomeres, to form particles which are immunologically indistinguishable from native virions. Experimentally induced VLP antisera have been shown to be mostly typespecific with respect to neutralization. Minor cross-neutralization has been observed only between closely related HPV types, e.g. HPV6 and 11, HPV18 and 45, or HPV16 and 31. Structure analysis has revealed the presence of several hyper variable loops on the outer surface of the capsid. With a few exceptions, all HPV-neutralizing monoclonal antibodies analyzed so far are type-specific and recognize conformational epitopes within surface-exposed hyper variable loops of the major capsid protein L1.
HPV16 L1抗体相关产品如下：
hz-7015R STK31丝氨酸/苏氨酸蛋白激酶31抗体
hz-4289R 5HT3B receptor5-羟色胺受体3B抗体
hz-6643R SCYL1BP1SCYL结合蛋白1抗体
hz-2959R 5HTR2C5-羟色胺受体2C抗体
hz-3660R srGAP3精神障碍相关GAP蛋白抗体
hz-3633R Synaptopodin突触足蛋白抗体
hz-2205R SLAMF9CD2F-10抗体
hz-4056R SMURF2Smad蛋白E3泛素连接酶2抗体
hz-2299R phospho-STMN2 (Ser50)磷酸化神经生长相关蛋白SCG10抗体
hz-7729R SMC5染色体结构维持蛋白5抗体
hz-7730R SMC6染色体结构维持蛋白6抗体
hz-7727R SMC2染色体结构维持蛋白2抗体
hz-7725R SA2粘结蛋白SA2抗体
hz-7728R SMC4染色体结构维持蛋白4抗体
hz-7724R Nuclear protein stromal antigen 1粘结蛋白SA1抗体
hz-7716R SPC25纺锤体极点构成蛋白25抗体
hz-12348R 5T4滋养层细胞糖蛋白5T4抗体
hz-1657R phospho-STAT1 (Tyr701)磷酸化信号转导与转录激活因子1抗体
hz-1658R phospho-STAT3 (Tyr705)磷酸化信号转导和转录激活因子3抗体
hz-1791R phospho-STAT6 (Tyr641)磷酸化信号转导和转录激活因子6抗体
hz-3525R SIGLEC14唾液酸结合性免疫球蛋白样凝集素14抗体
hz-0089R Secretin receptor分泌素受体抗体
hz-1127R beta Sarcoglycan肌聚多糖-β抗体
hz-3433R Phospho-Syk (Tyr323)磷酸化非受体型酪氨酸蛋白激酶抗体
hz-3434R Phospho-Syk (Tyr525 + Tyr526)磷酸化非受体型酪氨酸蛋白激酶抗体
hz-0645R Rat secretory IgA分泌型免疫球蛋白A抗体
hz-1096R SKP2细胞S期激酶相关蛋白2抗体
hz-0763R Snake poison Protein蛇毒蛋白抗体（中华眼镜蛇）
hz-0495R Selenoprotein W硒蛋白W抗体
hz-0545R SCF干细胞生长因子抗体
hz-0783R SDF1 beta基质细胞衍生因子－1抗体
hz-1121R Sema3A臂板蛋白3A抗体
hz-1122R semaphorin 3F臂板蛋白3F抗体
hz-1123R Sema4C臂板蛋白4C抗体
hz-1128R SGLT1钠-糖共转运载体1抗体
hz-0211R SHANK 1富含脯氨酸突触相关蛋白SHANK1抗体
hz-1175R SHBG性激素结合球蛋白抗体
hz-1129R SHP-1造血细胞磷酸酶抗体
hz-1233R SHP2蛋白酪氨酸磷酸酶2抗体
hz-0496R SLC24A5可溶性载质转运蛋白SLC24A5抗体
hz-2121R SCYLV甘蔗SCYLV抗体
hz-2536R SREBP-2胆固醇调节元件结合蛋白2抗体
hz-2544R SLAMF7SLAMF7抗体
hz-6733R SECTM1分泌和跨膜蛋白1抗体
hz-6732R SDF4基质细胞衍生因子4抗体（钙结合蛋白）
hz-6737R SVH肝癌蛋白剪接变异体蛋白抗体
hz-7011R SDCCAG8结肠癌抗原8抗体
hz-7009R SART3T淋巴细胞识别的鳞状细胞癌SART3抗体
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HPV16 L1抗体
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