CLEC1B / CLEC2抗体

CLEC1B / CLEC2抗体产品信息

免疫原 :
Recombinant Human CLEC1B / CLEC2 Protein (Catalog #10976-H07H)
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 :
004
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant human CLEC1B / CLEC2 ( rh CLEC1B / CLEC2; Catalog #10976-H07H; Gln 58-Pro 229; NP_057593.3)
CLEC1B / CLEC2抗体Background
C-type lectin receptor 2, CLEC2, or CLEC1B is a 32kDa transmembrane glycoprotein belonging to the Dectin-1 subfamily of C-type lectin receptors. The myeloid CLEC2 is highly expressed on the surface of platelets and is found at low level at other hematopoietic cells. CLEC2 is typified by possessing an extracellular C-type lectin like domain and a single cytosolic tail. The cytosolic tail of CLEC2 contains a conserved YxxL sequence preceded by three upstream acidic amino acid residues, which together form a novel motif known as a hemITAM. CLEC2 activates platelets through interacting with Src and Syk tyrosine kinase. Ligand binding induces tyrosine phosphorylation of the hemITAM sequence providing docking site for the tandom-SH2 domains of the tyrosine kinase Syk. Tyrosine phosphorylation of Syk is induced by Src family kinases and leads to a serious of downstream signaling cascade that culminates in activation of phospholipase Cγ2. It has been reported that CLEC2/CLEC1B mediates powerful platelet aggregation by binding to the snake venom toxin, rhodocytin. Besides, it has been hypothesized that endogenous ligand for CLEC2 in renal cells expressing human immunodeficiency virus type 1(HIV1).
CLEC1B / CLEC2抗体相关产品如下：
hz-3584R Ulex Europaeus Lectin 1荆豆凝集素1抗体
hz-6748R UBAP1泛素相关蛋白1抗体（鼻咽癌相关基因20蛋白）
hz-6749R Ubiquitously expressed transcript广泛表达转录蛋白UXT抗体
hz-13006R Ubiquitin D泛素D抗体
hz-4760R Uteroglobin子宫珠蛋白抗体
hz-5094R UROD尿卟啉原脱羧酶抗体
hz-5640R phospho-SLAMF1 (Tyr281)磷酸化信号淋巴细胞活化分子CD150抗体
hz-4257R Ube2B泛素激活酶2B抗体
hz-3761R UAP56ATP-依赖的RNA解旋酶p47抗体
hz-1403R USF-1等上游刺激因子1抗体
hz-8571R Histone H2A.X (Ubiquityl Lys119)泛素化组蛋白H2AX抗体
hz-6426R UromodulinTH糖蛋白抗体
hz-7846R SKA1纺锤体和着丝粒相关蛋白1抗体
hz-9184R VGLL3转录辅助因子退变样蛋白3抗体
hz-9182R VGLL1转录辅助因子退变样蛋白1抗体
hz-8718R Viperin病毒抑制蛋白Viperin抗体
hz-4754R VWF血管假性血友病因子/血管性血友病因子抗体
hz-10071R VEGFB167 血管内皮生长因子B167
hz-10072R VEGFB血管内皮生长因子B
hz-0925R V.cholera Ogawa01群稻叶型霍乱弧菌抗体
hz-1505R VASH1血管抑制蛋白1抗体
hz-2109R V5 tagV5 tag标签抗体
hz-2110R VSV-G tagVSV-G tag标签抗体
hz-1313R VEGF血管内皮生长因子抗体
hz-0197R VPAC2R腺苷酸环化酶激活肽受体-II/血管活性肠肽受体-II抗体
hz-4258R Vesicle docking protein p115囊泡对接蛋白p115抗体
hz-4572R VEGF-A血管内皮生长因子A
hzm-4572M VEGF-A小鼠抗血管内皮生长因子A抗体
hz-6640R Vinculin粘着斑蛋白抗体
hz-6677R VAT1嗜铬颗粒胺转运蛋白VAT1抗体
hz-3915R Vitamin D Binding protein维生素D结合蛋白抗体
hz-7695R VNN1血管非炎症分子1抗体
hz-10048R Von Willebrand Factor血管假性血友病因子/血管性血友病因子抗体
hz-1586R VEGF-C血管内皮生长因子C型抗体
hz-1952R VAMP3囊泡相关膜蛋白3抗体
hz-1953R VPS18空泡分选蛋白18抗体
hz-3471R Phospho-Vimentin (Ser56)磷酸化波形蛋白抗体
hz-3472R Phospho-Vimentin(Ser82)磷酸化波形蛋白抗体
hz-4167R VAV1鸟苷酸转换因子VAV1抗体