CLEC1B / CLEC2抗体

CLEC1B / CLEC2抗体产品信息免疫原 : Recombinant Human CLEC1B / CLEC2 Protein (Catalog #10976-H07H)

Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 004
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant human CLEC1B / CLEC2 ( rh CLEC1B / CLEC2; Catalog #10976-H07H; Gln 58-Pro 229; NP_057593.3)
CLEC1B / CLEC2抗体 Background
C-type lectin receptor 2, CLEC2, or CLEC1B is a 32kDa transmembrane glycoprotein belonging to the Dectin-1 subfamily of C-type lectin receptors. The myeloid CLEC2 is highly expressed on the surface of platelets and is found at low level at other hematopoietic cells. CLEC2 is typified by possessing an extracellular C-type lectin like domain and a single cytosolic tail. The cytosolic tail of CLEC2 contains a conserved YxxL sequence preceded by three upstream acidic amino acid residues, which together form a novel motif known as a hemITAM. CLEC2 activates platelets through interacting with Src and Syk tyrosine kinase. Ligand binding induces tyrosine phosphorylation of the hemITAM sequence providing docking site for the tandom-SH2 domains of the tyrosine kinase Syk. Tyrosine phosphorylation of Syk is induced by Src family kinases and leads to a serious of downstream signaling cascade that culminates in activation of phospholipase Cγ2. It has been reported that CLEC2/CLEC1B mediates powerful platelet aggregation by binding to the snake venom toxin, rhodocytin. Besides, it has been hypothesized that endogenous ligand for CLEC2 in renal cells expressing human immunodeficiency virus type 1(HIV1).
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