FLRG抗体

FLRG抗体产品信息

免疫原 :
Recombinant Mouse FLRG protein (Catalog#50029-M08H)
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 :
131
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse FLRG / Fstl3 (rM FLRG / Fstl3; Catalog#50029-M08H; NP_113557.1; Met 1-Val 256).
FLRG抗体 Background
FLRG (follistatin-related gene) protein is a follistatin-like protein which contains two FS domains and acts as a binding protein for activin and BMP-2. FLRG is a secreted glycoprotein that is highly homologous with follistatin. These proteins are involved in the regulation of various biological effects mediated by their binding to TGF-β superfamily members, activin A and bone morphogenetic proteins.The mouse FLRG gene consists of five exons, and each encodes discrete functional regions.Although mouse and human FLRGs show some divergence compared with follistatins, structurally they are conserved, also, domain organization and putative Asn-linked glycosylation sites are completely conserved. Both mouse and human FLRG have an NH2-terminal domain, two FS domains that are thought to have growth factor-binding motifs, and a COOH-terminal acidic domain. Recombinant mouse FLRG protein binds to activin A and BMP-2, and blocked the activities of acitvin A, activin B, activin AB, and BMP-2. Mouse FLRG mRNA is abundantly expressed in heart, lung, kidney, and testis. FLRG is also expressed in the mouse ovary, suggesting that FLRG plays physiological roles in the regulation of ovarian function as follistatin does.
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