Mouse TIMD4 / TIM4抗体

Mouse TIMD4 / TIM4抗体产品信息

免疫原 :
Recombinant mouse TIMD4 protein ( Catalog#50388-M08H )
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant mouse TIMD4 ( rM TIMD4 ; Catalog#50388-M08H ; NP_848874.3 ; Met 1 - Thr 279 ). TIMD4 specific IgG was purified by mouse TIMD4 affinity chromatography.
Mouse TIMD4 / TIM4抗体Background
Mouse T-cell immunoglobulin and mucin domain-containing protein 4, also known as T-cell membrane protein 4, TIMD4, and TIM4, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and TIM family. TIM4 contains one Ig-like V-type (immunoglobulin-like) domain. It is expressed on dendritic cells and macrophages. TIM4 plays an important role in the proliferation of T helper type 2 (Th2) cells. TIM4 is involved in regulating T-cell proliferation and lymphotoxin signaling. It is a ligand for HAVCR1 / TIMD1. The expression of TIM4 in fibroblasts enhanced their ability to engulf apoptotic cells. TIM4 and TIM1 are phosphatidylserine receptors for the engulfment of apoptotic cells, and may also be involved in intercellular signalling in which exosomes are involved. Modulation of TIM4 production in dendritic cells (DCs) represents a novel therapeutic approach for the treatment of peanut allergy.
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