2B4 / CD244抗体

2B4 / CD244抗体产品信息

免疫原 :
Recombinant Human 2B4 / CD244 protein (Catalog#10042-H08H)
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 :
020
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was obtained from a rabbit immunized with purified, recombinant Human 2B4 / CD244 (rh 2B4 / CD244; Catalog#10042-H08H; NP_057466.1; Met 1-Arg 221)
2B4 / CD244抗体 Background
The CD244 antigen, also known as 2B4, is a cell surface glycoprotein implicated in the regulation of natural killer and T lymphocyte function. The 2B4 antigen identified on NK cells and T cells is capable of transmitting stimulatory signals and non-MHC-restricted killing. Reported as an activating receptor, human 2B4 can effectively activate and enhance NK cell-mediated cytotoxicity, induce secretion of IFN-γ and matrix metalloproteinases (MMPs), as well as NK cell invasiveness. As a member of the CD2 subset of the Ig superfamily, CD244 is a high affinity ligand for CD48 and the interaction is essential for generation of NK effectors.
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