CD147 / EMMPRIN / Basigin抗体

CD147 / EMMPRIN / Basigin抗体产品信息

免疫原 :
Recombinant Human CD147 / EMMPRIN / Basigin protein (Catalog#10186-H08H)
Reagents : PE-conjugated rabbit monoclonal antibody
Clone ID :
125
抗体宿主 :
Rabbit IgG
Concentration :
5 μl/Test, 0.1 mg/ml
缓冲液 : Aqueous solution containing 0.5% BSA and 0.09% sodium azide
制备方法 :
This antibody was obtained from a rabbit immunized with purified, recombinant Human WFDC2 / HE4 (rh WFDC2 / HE4; Catalog#12609-H08H; NP_006094.3; Met1-Phe124) and conjugated with PE under optimum conditions, the unreacted PE was removed.
CD147 / EMMPRIN / Basigin抗体 Background
CD147, also known as BSG or EMMPRIN, is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence variants. CD147 is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis, embryo implantation, neural network formation, and tumor progression. Enriched on the plasma memebrane of many human cancer (breast cancer, lymphoma, oral squamous cell carcinoma, glioma, melanoma, lung, bladder and kidney carcinomas) cells, CD147 induces the production and release of matrix metalloproteinases in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Furthermore, CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction.
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