BCAM抗体

BCAM抗体产品信息

免疫原 :
Recombinant Rat BCAM protein (Catalog#80222-R08H)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, recombinant Rat BCAM (rR BCAM; Catalog#80222-R08H; Q9ESS6; Met1-Ala543). Total IgG was purified by Protein A affinity chromatography.
BCAM抗体 Background
Basal cell adhesion molecule (BCAM) and Lutheran blood group glycoprotein (LU) are two alternatively spliced variants of a single pre-mRNA. They are type I membrane proteins of the immunoglobulin superfamily (IgSF) sharing similar structure characteristics except for the length of cytoplasmic tails. The mature 597 amino acid BCAM contains an extracellular domain composing of five Ig-like domains (two V-set and three C2-set) , a single transmembrane domain, and a 19aa cytoplasmic domain which lacks the putative Src homology 3 (SH3) binding site compared to the 59aa cytoplasmic domain present in LU. BCAM/LU has a wide tissue distribution with a predominant expression in the basal layer of the epithelium and the endothelium of blood vessel walls. As designated as CD239 recently, BCAM and LU share a significant sequence similarity with the CD146 (MUC18) and CD166, and themselves are adhesion molecules that bind laminin with high affinity. Laminins are found in all basement membranes and are involved in cell differentiation, adhesion, migration, and proliferation. It has been shown that BCAM expression is upregulated following malignant transformation in some cell types in vivo and in vitro, and BCAM is identified as a marker of epithelial ovarian cancers. In addition, BCAM interacts with integrin in sickle red cells, and thus may potentially play a role in vaso-occlusive episodes.
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