Coagulation Factor XI / F11抗体

Coagulation Factor XI / F11抗体产品信息

免疫原 :
Recombinant Human Coagulation Factor XI / F11 protein (Catalog#10302-H08H)
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 :
007
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was obtained from a rabbit immunized with purified, recombinant Human Coagulation Factor XI / F11 (rh Coagulation Factor XI / F11; Catalog#10302-H08H; NP_000119.1; Met1-Val625).
Coagulation Factor XI / F11抗体 Background
Factor XI (plasma thromboplastin antecedent) is a plasma glycoprotein, and a zymogen acting as a serine protease which participates in blood coagulation as a catalyst in the conversion of factor IX to factor IXa in the presence of calcium ions. The factor XI is synthesized in the liver as a single polypeptide chain with a molecular weight estimated between 125 ~160 kDa and then is processed into a disulfide-bond linked homodimer. Factor XI is is converted to an active protease, factor XIa, by factor XIIa (or factor XII) in the presence of high molecular weight kininogen (HMWK) and a polyanionic surface. After the activation reaction, Factor XIa is composed of two heavy and two light chains held together by three disulfide bonds. The heavy chains are derived from the amino termini of the zymogen and responsible for the binding of factor XI to high molecular weight kininogen and for the activation of factor IX, while the light chain contains the catalytic portion of the enzyme and is homologous to the trypsin family of serine proteases. FXI deficiency is a disorder characterized by a mild or no bleeding tendency. The vast majority of the FXI deficiencies have been found in the Ashkenazi Jewish population.
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