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- 2025年07月15日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
常温，避光
- 克隆性：
单克隆
- 抗体名：
IL6R / CD126抗体
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant human IL6 receptor extracellular domain ( rhIL6R; Catalog#10398-H08H; NP_000556.1; Met 1- Pro 365 ). IL6R specific IgG was purified by human IL6R affinity chromatography.
IL6R / CD126抗体背景综述
Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. The IL6 receptor is composed of two different subunits, IL6R that binds IL6 with low affinity, and ubiquitously expressed Glycoprotein 130 (gp130) which acts as a common signal-transducing receptor and binds the IL-6·IL-6R complex with high affinity. The IL6R , also known as CD126, is a type I transmembrane cytokine receptor and lacks a tyrosine/kinase domain within the cytoplasmic region, unlike other growth factor receptors. The soluble form of IL6R arises from proteolytic cleavage of membrane-bound IL6Rα, and acts agonistically by making the IL6 ligand accessible to the signal transducer gp130. Dysregulated production of IL6 and IL6R are implicated in the pathogenesis of several inflammatory diseases and malignancies such as multiple myeloma, rheumatoid arthritis, and osteoporosis. Humanized anti-IL6R monoclonal antibody is a promising agent applicable to the therapeutic approach for IL6 driven diseases.
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文献和实验（杨希峰），Yang CY（杨春瑛） et al. Generation and characterization of monoclonal antibody against HIT3a （抗CD3单克隆抗体HIT3a的制备和特异性鉴定）， Acta Academiae Medicinae Sinicae （中国医学科学院学报），1993， 15：157-162.[6] Xiong D S（熊冬生），Yang C Z（杨纯正），Shao X F（邵晓枫）et al. Generation
因为抗体的结合而减少；在人体血清中无游离的CD20存在；最重要的是B淋巴细胞瘤上的CD20少有内吞和脱落的发生[ 2-5 ] 。1997年，以CD20为靶点的嵌合抗CD20单克隆抗体Rituxan已获准应用于B细胞淋巴瘤的治疗[ 6 ]。HI47（IgG3）是我所于1990年研制成功的国内第一个抗CD20鼠源性单克窿抗体，第四届国际人类白细胞分化抗原会议将HI47命名为CD20+X[ 7 ] 。我们利用噬菌体显示技术从HI47杂交瘤细胞中克隆到抗CD20抗体HI47可变区基因，将该基因构建成为嵌合的抗
20B淋巴细胞表面的膜蛋白CD20对B淋巴细胞的增殖和分化具有调节作用[1]。由于CD20分子仅在前-B淋巴细胞、未成熟B淋巴细胞、成熟B淋巴细胞、激活B淋巴细胞中表达，而在浆细胞、淋巴多能干细胞以及其它组织均无CD20的表达[2，3，4]，在人体血清中亦无游离CD20的存在[5]，因此CD20可作为B淋巴细胞瘤治疗的一个理想治疗靶点。限制抗体临床使用的因素主要有抗体产生的免疫原性和抗体的生产能力是否能够满足临床需要。第四届国际人类白细胞分化抗原会议将鼠源性单克隆抗CD20抗体HI47（IgG3）正式命名为CD20+X
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