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- 详细信息
- 技术资料
- 保存条件:
常温,避光
- 克隆性:
单克隆
- 抗体名:
FCGR2B / CD32抗体
Ig Type : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant mouse FCGR2B / CD32 extracellular domain ( rM FCGR2B; Catalog#50030-M08H; Met 1- Ala 217; NP_001070657.1 ). FCGR2B specific IgG was purified by mouse FCGR2B affinity chromatography.
FCGR2B / CD32抗体 Background
FcγRII (CD32) is a low affinity receptor for IgG that binds only IgG immune complexes and is expressed on a diverse range of cells such as monocytes, macrophages, neutrophils, eosinophils, platelets, and B cells. There are three main classes of human leucocyte IgG Fc receptor (FcγR): FcγRI (CD64), FcγRII (CD32), and FcγRⅢ (CD16) which are distinguished on the basis of molecular weights, cellular distribution, affinity/specificity for ligand and by reactivity with monoclonal antibodies. Many important functions have been attributed to these receptors and they are regarded as providing an essential link between cellular and humoral immune systems. The most ubiquitous of these receptors is FcγRII. The extracellular region of FcγRII comprises two C2-type Ig-like disulfide-bonded domains which is structurally conserved in all of the Ig superfamily leukocyte FcRs (and represents an Ig-interactive motif. FcγRII is involved in a number of immune responses including antibody-dependent cell-mediated cytotoxicity, clearance of immune complexes, release of inflammatory mediators, and regulation of antibody production.
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