CD40 / TNFRSF5 / Bp50抗体

Human tumor necrosis factor receptor superfamily member 5, also known as CD40 and TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins, and plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 contains 4 cysteine-rich repeats in the extracellular domain, and is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. The cognate interaction between CD40 and CD40 ligand (CD154) on T cells activates NF-kappa B, Jun N-terminal kinase, and Janus kinase signal transducers and activators of transcription pathways. Several different TRAF proteins (Adaptor proteins) have been identified to serves as mediators of the signal transduction. In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3), an autosomal recessive disorder characterized by an inability of B cells to undergo isotype switching, as well as an inability to mount an antibody-specific immune response, and a lack of germinal center formation.
CD40 / TNFRSF5 / Bp50抗体相关产品如下：xy-1530R Slc4a7碳酸氢钠协同转运蛋白4-A7抗体
xy-9463R SYNC微管卷曲蛋白SYNC抗体
xy-3398R Phospho-SHIP1 (Tyr1020)磷酸化SH2结构含磷酸肌醇SHIP1抗体
xy-3393R Phospho-SIRT1(Ser47)磷酸化沉默调节蛋白1抗体
xy-1298R Smac线粒体促凋亡蛋白抗体
xy-11784R SPR墨蝶蛉还原酶抗体
xy-11787R alpha + beta Synuclein核突触蛋白α+β抗体
xy-11671R SPFH2内质网脂质转运相关蛋白2抗体
xy-11673R Serine racemase丝氨酸消旋酶
xy-11754R SCGN钙结合样蛋白/神经内分泌肿瘤标记物抗体
xy-11755R SFRS7丝氨酸/苏氨酸蛋白激酶SRPK7抗体
xy-11756R SGSH磺氨基葡糖硫酸胺酶抗体
xy-11757R SMUBP2免疫球蛋白μ链结合蛋白2抗体
xy-11785R SPG21痉挛性截瘫相关蛋白21抗体
xy-11759R SPG3AG蛋白结合蛋白3抗体
xy-11760R SPG48SPG48蛋白抗体
xy-11761R SPG7痉挛性截瘫蛋白7/基质细胞粘附调节蛋白抗体
xy-11762R SPTBN2非红细胞血影脑蛋白β2/spectrin β III抗体
xy-11763R SULT4A1脑磺基转移酶样蛋白4A1抗体
xy-11765R Synaptotagmin-14突触结合蛋白14抗体
xy-11766R TBPTATA结合蛋白TBP抗体
xy-11767R TBCE微管蛋白特定伴侣蛋白E抗体
xy-11768R TDRD3Tudor结构域蛋白TDRD3抗体
xy-11769R TIMM8A线粒体内膜转位酶8A/耳聋/肌张力障碍肽抗体
xy-11770R TMEM158跨膜蛋白158抗体
xy-11771R TTBK2Tau微管蛋白激酶2抗体
xy-11773R Transglutaminase 6谷氨酰胺转胺酶6抗体
xy-11648R TMEM59L跨膜蛋白59样蛋白抗体
xy-11775R Twinkle共济失调蛋白8抗体
xy-11603R TBR1TBR1蛋白抗体
xy-11605R TULP3感光细胞转录因子TULP3抗体
xy-11607R TsukushinTSK蛋白抗体
xy-11614R TAS2R5味觉受体蛋白家族2亚基5抗体
xy-11674R TPPP微管蛋白聚合促进蛋白24