IL-3抗体

IL-3抗体产品信息免疫原 : Recombinant Human IL-3 protein (Catalog#11858-H08B)

Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 001

抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Human IL-3 (rh IL-3; Catalog#11858-H08B; NP_000579.2; Met 1-Phe 152).
IL-3抗体 Background
Interleukin-3, also known as Hematopoietic growth factor, Mast cell growth factor, Multipotential colony- stimulating factor, P-cell-stimulating factor and IL3, is a secreted protein which belongs to theIL-3 family. Interleukin-3 originally was discovered by JN Ihle in mice. He found a T cell derived factor that induced the synthesis of 20 alpha-hydroxysteroid dehydrogenase in hematopoietic cells and termed it interleukin-3. Interleukin-3 / IL-3 is an interleukin, a type of biological signal (cytokine) that can improve the body's natural response to disease as part of the immune system. It acts by binding to the interleukin-3 receptor. Interleukin-3 / IL-3 stimulates the differentiation of multipotent hematopoietic stem cells into myeloid progenitor cells (as opposed to lymphoid progenitor cells where differentiation is stimulated by IL-7) as well as stimulates proliferation of all cells in the myeloid lineage (erythrocytes, megakaryocytes, granulocytes, monocytes, and dendritic cells). Interleukin-3 / IL-3, which is an hematopoietic growth factor as well as an important factor that aids in embryo implantation and placental development, was found to be decreased both in pregnant women with antiphospholipid syndrome (APS) and in animal models of APS. Interleukin-3 / IL-3 also participates in the response of the organism to various types of stress.
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