CD40 / TNFRSF5抗体

CD40 / TNFRSF5抗体产品信息免疫原 : Recombinant human CD40 protein ( Catalog#10774-H08H )

Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 4
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant human CD40 extracellular domain ( rh CD40; Catalog#10774-H08H; NP_001241.1 ; Met 1 - Arg 193 ).
CD40 / TNFRSF5抗体背景综述
Human tumor necrosis factor receptor superfamily member 5, also known as CD40 and TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins, and plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 contains 4 cysteine-rich repeats in the extracellular domain, and is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. The cognate interaction between CD40 and CD40 ligand (CD154) on T cells activates NF-kappa B, Jun N-terminal kinase, and Janus kinase signal transducers and activators of transcription pathways. Several different TRAF proteins (Adaptor proteins) have been identified to serves as mediators of the signal transduction. In addition, CD40 / CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3), an autosomal recessive disorder characterized by an inability of B cells to undergo isotype switching, as well as an inability to mount an antibody-specific immune response, and a lack of germinal center formation.
CD40 / TNFRSF5抗体相关产品如下：xy-9321R PRPF4PRPF4蛋白抗体
xy-2036R Penicillin G青霉素G抗体
xy-6976R Phospholipase C beta 1磷酯酶Cβ1抗体
xy-7619R PSRC1富含脯氨酸/丝氨酸卷曲螺旋蛋白1抗体
xy-6966R p47-phoxNADPH氧化酶活化蛋白p47抗体
xy-9349R Proteasome 19S S7蛋白酶体PRS7抗体
xy-9350R Proteasome 20S C2蛋白酶体PSMα1抗体
xy-9351R Proteasome 20S alpha 2蛋白酶体PSMα2抗体
xy-9355R Proteasome 20S alpha 6蛋白酶体PSMα6抗体
xy-9356R PSMA7蛋白酶体PSMα7抗体
xy-9612R PIBF1孕酮诱导阻断因子1抗体
xy-9623R PARP16多腺苷二磷酸多聚酶16抗体
xy-9605R PITX2成对样同源结构域转录因子2抗体
xy-6972R RNA polymerase IIRNA聚合酶II抗体
xy-1364R PHLDA1T淋巴细胞凋亡相关蛋白TDAG51抗体
xy-1372R PSMD9蛋白酶调解因子9抗体
xy-8543R Pancreatic hormone胰腺激素抗体
xy-9844R PLGLB2纤溶酶相关蛋白B2抗体
xy-9435R PAPOL A+B+G多聚合酶α/β/γ抗体
xy-11198R ProSAPiP1 含脯氨酸突触相关蛋白相互作用蛋白1抗体
xy-11197R PRPH2外周蛋白2抗体
xy-11176R Pregnancy zone protein妊娠区带蛋白PZP抗体
xy-9548R PGGT1B蛋白香叶烯基转移酶1β（FTβ）抗体
xy-11134R PCDHB15原钙粘蛋白15抗体
xy-11136R PCDHB2原钙粘蛋白β2抗体
xy-11138R PCDHB4原钙粘蛋白β4抗体
xy-11143R PCDHGA10原钙粘蛋白γ10抗体
xy-11144R PCDHGA4原钙粘蛋白γA4抗体
xy-11145R PCDHGA2原钙粘蛋白γA2抗体
xy-11147R PCDHGA5原钙粘蛋白γA5抗体
xy-11148R PCDHGA7原钙粘蛋白γA7抗体
xy-11149R PCDHGA8原钙粘蛋白γA8抗体
xy-11150R PCDHGA9原钙粘蛋白γA9抗体
xy-11151R PCDHGA11原钙粘蛋白γA11抗体
xy-11152R PCDHGA12原钙粘蛋白γA12抗体