CD74 / DHLAG / p33 抗体

Human CD74, also known as HLA-DR antigens-associated invariant chain or Ii, is a non-polymorphic glycoprotein, which is expressed on antigen-presenting cells (APC), and carcinomas of renal, lung, gastric, thymic origin and by certain sarcomas. It is post-translationally glycosylated and exists in different isoforms. The most common isoform is 33 kDa (p33), but p35, p41 and p43 isoforms also exist. The most well-known function of CD74 is regulating the trafficking of class Ⅱ major histocompatibility complex (MHC) proteins in APC. It also acts as a surface membrane receptor for macrophage migration inhibitory factor (MIF), alone or together with CD44. But multiple studies have revealed that cell surface expression of CD74 is not always dependent on class Ⅱ MHC. The role of CD74 in signal transduction was initially hypothesized when it was found to be phosphorylated and associated with proteins that coordinate various signal transduction pathways. CD74 was recently found to be increased in microglia in Alzheimer disease (AD) cases compared to age-matched controls. Additionally, it may be useful targets to reduce neutrophilic lung inflammation, and acute lung injury. Various studies have indicated that CD74 is highly expressed in inflammatory disorders and cancers. Thus, the restricted expression of CD74 by normal tissues and its very rapid internalization make CD74 an attractive therapeutic target for both cancer and immunologic diseases.
CD74 / DHLAG / p33 抗体相关产品如下：xy-4848R phospho-RUNX3(Ser338)磷酸化Runx3抗体
xy-2933R RAB-14RAS相关蛋白癌基因Rab14抗体
xy-5696R phospho-p107(Ser975)磷酸化视网膜母细胞瘤样蛋白p107抗体
xy-5697R phospho-RelB(Ser551)磷酸化转录因子RelB蛋白抗体
xy-2163R RNF148环指蛋白148抗体
xy-2794R RGS5G蛋白信号转导调节因子5抗体
xy-2777R Rb成视网膜细胞瘤基因抗体
xy-2149R SPRN新朊蛋白抗体
xy-4188R SGPL1磷酸鞘氨醇裂解酶1抗体
xy-7358R se-selectin可溶性E选择素
xy-8620R sp-selectin可溶性P选择素抗体
xy-1888R SCG3分泌粒蛋白3抗体
xy-1034R SP-B肺表面活性蛋白B抗体
xy-1135R SRCsrc原癌基因抗体
xy-1220R SPAG4L生精细胞凋亡相关基因4抗体
xy-3600R Syntrophin Alpha1神经肌肉接头蛋白SNTA1抗体
xy-1331R sFRP-4子宫内膜抗体
xy-7934R SHOC2富含亮氨酸重复蛋白SHOC2抗体
xy-7772R SEPT14细胞分化蛋白SEPT14抗体
xy-11952R SLC12A6钾氯离子转运蛋白3抗体
xy-11953R SLC25A12钙结合线粒体载体蛋白抗体
xy-11954R SLC5A3钠离子肌醇转运蛋白抗体
xy-11693R Senataxin肌萎缩侧索硬化症相关蛋白4抗体
xy-11702R SH3GL3胞浆蛋白SH3GL3抗体
xy-10149R ABCG8三磷酸腺苷结合转运蛋白G超家族成员8抗体
xy-11955R SLITRK2神经突触相关蛋白SLITRK2抗体
xy-11956R SLITRK3神经突触相关蛋白SLITRK3抗体
xy-11957R SLITRK4神经突触相关蛋白SLITRK4抗体
xy-11959R SLITRK5神经突触相关蛋白SLITRK5抗体
xy-11960R SLITRK6神经突触相关蛋白SLITRK6抗体
xy-11961R SNAIL + SLUG锌指转录因子Slug+SNAIL抗体
xy-11962R phospho-SNAIL + SLUG (Ser246)磷酸化锌指转录因子Slug+SNAIL抗体
xy-11963R SORCS2液泡蛋白分选受体SORCS2抗体
xy-11964R SOX21转录因子21抗体
xy-11965R SPOCK1睾丸蛋白聚糖1抗体
xy-11966R SPOCK2睾丸蛋白聚糖2抗体