CD2 / LY37抗体

CD2 / LY37抗体产品信息免疫原 : Recombinant mouse CD2 protein ( Catalog#50537-M08H )

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant mouse CD2 ( rh CD2 ; Catalog#50537-M08H ; NP_038514.1 ; Met 1 - Ser 203 ). Total IgG was purified by Protein A affinity chromatography
CD2 / LY37抗体背景综述
Mouse T-cell surface antigen CD2, also known as T-cell surface antigen T11/Leu-5, Erythrocyte receptor, Rosette receptor, CD2 and SRBC, is a single-pass type I membrane protein. CD2 contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48 / BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function. The CD2 family of receptors is evolutionarily conserved and widely expressed on cells within the hematopoietic compartment. CD2 family members regulate natural killer (NK) cell lytic activity and inflammatory cytokine production when engaged by ligands on tumor cells. The complex of CD2 and CD58 plays an important role in enhancing the adhesion of T lymphocytes to target cells, and promoting hyperplasia and activation of T lymphocytes. The expression of CD2 significantly increased with the severity of chronic HBV infection, which suggested that CD2 might contribute to the hepatocyte damage in chronic HBV infection.
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