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Description | Purified Monoclonal Antibody against Prion protein, 6D11 (Formerly Signet Laboratories Catalog Nos: 9810-02, 9810-05, 9810-10) |
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Intended Use | **Research Use Only (RUO)** This product is sold for laboratory research use only, not for human or in-vivo use. |
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Clone | 6D11 | |
Form | Purified Antibody (in PBS; no preservatives or carrier proteins) | |
Host | Mouse | |
Species Reactivity | Prion (6D11) Monoclonal Antibody, Purified (SIGNET)Human, Bovine, Sheep, Mule Deer, Elk, Mouse, Hamster | |
IsoType | IgG2a, kappa | |
[Ab] | 2.0 mg/mL | |
Specificity | 6D11 reacts with both the PrPc and PrPsc forms. The epitope falls within amino acids 93-109 of PrP. This monoclonal antibody produced in the Integra flask system using serum free media and was purified using protein A affinity chromatography. |
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Uses | This antibody is effective in immunoblotting, immunohistochemistry (IHC) and ELISA. | |
Suggested Working Dilution | The optimal working dilution should be determined for each specific assay condition.
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Storage | Prion (6D11) Monoclonal Antibody, Purified (SIGNET)Store at -20°C or below. Upon initial thawing, apportion into working aliquots and store at -20°C or below. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. Do not store in frost-free freezers. | |
References | Laurén J, et al. Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Nature 457(7233):1128-32, 2009. Sadowski M, et al. Therapeutic mechanisms of anti- prion antibodies in a tissue culture model of prion infection. Am Soc Neurosci, San Diego, CA, Sep, 2005. Pankiewicz J, et al. Anti- monoclonal antibodies for prevention of prion infection. Soc Neurosci, Washington, DC, Nov, 2005. Sigurdsson EM, et al. Anti-prion antibodies for prophylaxis following prion exposure in mice. Neurosci Lett 336:185-187, 2003. Spinner DS et al. The role of components of the lymphoreticular system in transmissible spongiform encephalopathy pathogenesis and neuroinvasion. Curr Med Chem –Immun Endoc & Metab Agents 3:119-135, 2003. Adler V, et al. Small, highly structured RNAs participate in the conversion of human recombinant PrPSen to PrPRes in vitro. J Mol Biol 332:47-57, 2003. Spinner DS, et al. Innate immune stimulation greatly enhances anti-PrP antibody production in prion protein immunized mice. SFN, New Orleans, LA, Nov 2003. Kascsak RJ, et al. Analysis of parameters influencing the ability to isolate hybridoma clones specific to TSE protein PrP. Conference on transmissible spongiform encephalopathies 2002. Edinburgh, Scotland, 2002. Kascsak RJ, et al. Immunodiagnosis of prion disease. Immunol Invest 26(1-2):259-68, 1997. Kascsak et al. (1993). The role of antibodies to PrP in the diagnosis of transmissible spongiform encephalopathies. Dev Biol Stand 80:141-151, 1993 Kascsak et al. Mouse polyclonal and monoclonal antibody to scrapie associated fibril proteins. J Virol 61:3688-3693, 1987. |
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Warranty/Conditions | Covance products may not be resold or modified for resale without prior written approval. |
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