ISG15抗体

ISG15抗体产品信息免疫原 : Recombinant Human ISG15 protein (Catalog#12729-HNAE)

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Human ISG15 (rh ISG15; Catalog#12729-HNAE; AAH09507.1; Met 1-Ser 165). ISG15 specific IgG was purified by Human ISG15 affinity chromatography.
ISG15抗体 Background
Ubiquitin-like protein ISG15, also known as Interferon-induced 15 kDa protein, Interferon-induced 17 kDa protein, Ubiquitin cross-reactive protein, ISG15 and G1P2, is a cytoplasm and secreted protein which is detected in lymphoid cells, striated and smooth muscle, several epithelia and neurons. ISG15 / G1P2 contains 2 ubiquitin-like domains. ISG15 / G1P2 is a ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. ISG15 / G1P2 enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 / G1P2 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. ISG15 / G1P2 Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. ISG15 / G1P2 is deconjugated by USP18/UBP43. It shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. ISG15 / G1P2 may serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. ISG15 / G1P2 may also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. ISG15 / G1P2 seems to display antiviral activity during viral infections.
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