LGALS3 / Galectin-3抗体

LGALS3 / Galectin-3抗体产品信息免疫原 : Recombinant Human LGALS3 / Galectin-3 protein (Catalog#10289-HNAE)

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Human LGALS3 / Galectin-3 (rh LGALS3 / Galectin-3; Catalog#10289-HNAE; P17931; Met1-Ile250). LGALS3 / Galectin-3 specific IgG was purified by Human LGALS3 / Galectin-3 affinity chromatography.
LGALS3 / Galectin-3抗体 Background
Galectin-3, also known as 35 kDa lectin, Carbohydrate-binding protein 35, Galactose-specific lectin 3, Galactoside-binding protein, IgE-binding protein, Laminin-binding protein, Lectin L-29, Mac-2 antigen and LGALS3, is a cytoplasm, nucleus and secreted protein which contains onegalectin domain. A major expression of Galectin-3 / LGALS3 is found in the colonic epithelium. It is also abundant in the activated macrophages. Galectin-3 / LGALS3 is a galactose-specific lectin which binds IgE. Galectin-3 / LGALS3 may mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus, Galectin-3 / LGALS3 acts as a pre-mRNA splicing factor. It is involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.
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