-CSFR / CSF1R / CD115抗体

M-CSFR / CSF1R / CD115抗体产品信息免疫原 : Recombinant human M-CSFR / CD115 protein ( Catalog #10161-H08H )

抗体类型: Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
1H10A7A4
抗体宿主 : Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human M-CSFR extracellular domain ( rh M-CSFR; Catalog #10161-H08H; Met 1- Glu 512; NP_005202.2 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
M-CSFR / CSF1R / CD115抗体背景综述
Macrophage colony-stimulating factor 1 receptor, also known as colony stimulating factor 1 receptor, M-CFSR, CSF1R, and CD115, is a cytokine involved in the proliferation, differentiation, and activation of macrophages. As a member of the type Ⅲ subfamily of receptor tyrosine kinases (RTKs), M-CFSR is expressed mainly on cells of monocyte / macrophage lineage, and consists of an extracellular ligand-binding domain and a cytoplasmic protein tyrosine kinase (PTK) domain joined through a single transmembrane helix. Ligand binding induces the M-CFSR homodimerization, and leads to trans-phosphorylation of specific tyrosine and the subsequent signal transduction. This activated receptor exerts actions on multiple intracellular effectors which determine the magnitude and specificity of the biological responses, and mediates most if not all of the biological effects of the CSF1 cytokine, including cell growth, survival, differentiation and chemotaxis. Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia.
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