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- Abcam
- 中国/美国/德国
- xy10700-MM01
- 2025年07月09日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
常温，避光
- 克隆性：
单克隆
- 抗体名：
TEK / TIE2 / CD202b抗体
Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
7G3A7E12
抗体宿主 : Mouse IgG2b
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human TIE2 ( rh TIE2 ; Catalog#10700-H08H ; NP_000450.2 ; Met 1- Lys 745 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
TEK / TIE2 / CD202b抗体背景综述
Tie2/Tek, together with Tie1/Tie, are members of the receptor tyrosine kinase (RTK) subfamily, and possess a unique extracellular domain containing two immunoglobulin-like loop domains flanking three epidermal growth factor (EGF) repeats followed by three fibronectin-type I II repeats, and a split tyrosine kinase domain in the cytoplasmic region. Tie2 is expressed predominantly on endothelial and hematopoietic progenitor cells and is essential for blood vessel formation and maintenance. The identified ligand angiopoietin-1 (Ang-1) binds Tie2 receptor with high-affinity and induces the signaling pathway of both cell migration and cell survival via the related mediator such as GRB2 and SH-PTP2. Accordingly, the Tie2 may trigger crucial endothelial responses during embryonic vascular development and during pathologic vascular growth, as well as the inflammatory responses with the key regulator ABIN-2. It has revealed that Ang1-Tie2 signaling exerts different function at cell-cell contacts and cell-substratum contacts dependent upon the spatial localization of Tie2. Deficiency in Tie2 is associated with inherited venous malformations.
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文献和实验X性联无丙种球蛋白血症(X-linked agammagl，bulinemia，XLA)是临床上首次确定的体液免疫缺陷病，由Brutor于1952年报道，故又称Bruton病。XLA作为常见的原发性免疫缺陷病之一，特点为血清中各类免疫球蛋白缺乏，或只能测得微量的抗体。外周血和淋巴组织中B细胞减少或完全缺乏，淋巴结中无生发中心和浆细胞。本病起病早，在出生数月后当患儿体内的母源性抗体水平下降时开始发病。临床表现为反复化脓性感染，患者细胞免疫功能不受影响(部分患者有T细胞数量减少)，主要缺陷
蛋白A/G珠子孵育1小时。任何非特异吸附都可以通过这附加的一步清除掉。将上清（声处理的染色质）倒入一个新的管子中按照步骤4.2使用抗体和珠子。5. 洗脱和逆转交联1. 使用120ulElutionBuffer洗脱液加入蛋白A/G珠子中30°C摇晃15分钟洗脱DNA。2. 2000g，1分钟离心，将上清移入新的管子中。此时的样品可以冻存于-20°C3DNA可采用PCR纯化试剂盒（步骤3.2a）或者酚/氯仿沉淀（加入280ul洗脱液，步骤见3.2b）4DNA的数量水平可通过定量PCR来检测，引物和探针通常可以使
E-Z 96 X-press Plasmid Vacuum Protocol
with swinging-bucket rotor capable of 3,000 x g 2. Vacuum Manifold (Cat# Vac-03) 3. Vortex 实验步骤 1. Pick up a single colony from a fresh streaked selective plate and Inoculate 2-3 mL LB medium containing the appropriate
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