ACVR1B / ALK-4抗体

ACVR1B / ALK-4抗体产品信息免疫原 : Recombinant human ALK4 protein ( Catalog#10583-H08H )

Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 : 4E1C1F12
抗体宿主 : Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human ALK4 extracellular domain ( rh ALK4 ; Catalog#10583-H08H ; NP_004293.1 ; Met 1 - Glu 126 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
ACVR1B / ALK-4抗体背景综述
Activin receptor type-IB, also known as Serine/threonine-protein kinase receptor R2, Activin receptor-like kinase 4, ALK-4, and ACVRIB, is a single-pass type I membrane protein which belongs to the protein kinase superfamily and TGFB receptor subfamily. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. ALK-4 is expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver. ALK4 and ALK7 can mediate signal transduction by Nodal proteins, although ALK7 appears to be a receptor more specifically dedicated to Nodal signaling.
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