Endoglin / CD105抗体

Endoglin / CD105抗体产品信息免疫原 : Recombinant human CD105 protein ( Catalog#10149-H08H )

Reagents : FITC-conjugated mouse monoclonal antibody
克隆号 : 4A3G3D3
抗体宿主 : Mouse IgG2b

Concentration : 10 μl/Test, 0.1 mg/ml
缓冲液 : Aqueous solution containing 0.5% BSA and 0.09% sodium azide
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human Endoglin / CD105 ( rh CD105 ; Catalog#10149-H08H ; Met 1 - Gly 586 ; NP_001108225.1 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography and conjugated with FITC under optimum conditions, the unreacted FITC was removed
Endoglin / CD105抗体 Background
Endoglin, also known as CD105, is a type I homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated, cytoplasmic tail. Endoglin contains an RGD tripeptide, a key recognition structure in cellular adhesion, and suggests a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type II receptor (TβRII) and activates the downstream signal pathway. In addition, ALK-1 is also a receptor kinase in human umbilical vein endothelial cells for endoglin threonine phosphorylation, and mutations in either result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful marker of neovascularization, and associated with several solid tumor types.
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