CD226 / DNAM-1 / PTA1抗体

CD226 / DNAM-1 / PTA1抗体产品信息免疫原 : Recombinant mouse CD226 protein ( Catalog#50232-M08H )

抗体类型: Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 26
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant mouse CD226 / DNAM-1 ( rM CD226; Catalog#50232-M08H; NP_848802.2; Met 1 - Pro 254 ).
CD226 / DNAM-1 / PTA1抗体背景综述
Mouse leukocyte adhesion molecule DNAM1, also known as CD226, is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. DNAM1 is identified as an intercellular adhesion molecule which are constitutively expressed on the majority of CD4+ and CD8+ T lymphocytes, natural killer (NK) cells, monocytes/macrophages, and a subset of B lymphocytes. The poliovirus receptor (PVR or CD155) and its family member nectin 2 (CD112) have been identified as the ligands for DNAM1. Interaction of DNAM1 with the ligands induces NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. DNAM1 also plays an important role in immune surveillance of tumor development and is involved in triggering naive T cell differentiation and proliferation. Similarly, murine DNAM1 and PVR homologues physically and functionally bind each other in vivo, and ligand binding of murine DNAM-1 induced a costimulatory signal in antigen-specific CD8+ T cells. Within the ECD, mouse DNAM1 shares 52% and 86% aa sequence identity with human and rat DNAM1, respectively.
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