CD226 / DNAM-1抗体

CD226 / DNAM-1抗体产品信息免疫原 : Recombinant human CD226 protein ( Catalog#10565-H08H )

Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 102
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant human CD226 / DNAM-1 ( rhCD226 ; Catalog#10565-H08H ; NP_006557.2 ; Met 1 - Asn 247 ).
CD226 / DNAM-1抗体背景综述
The leukocyte adhesion molecule DNAM1, also known as CD226, is a transmembrane glycoprotein consisting of 318 amino acid including two Ig-like domains. As a member of the immunoglobulin superfamily, DNAM1 is also an intercellular adhesion molecule which are constitutively expressed on the majority of CD4+ and CD8+ T lymphocytes, natural killer (NK) cells, monocytes / macrophages, and a subset of B lymphocytes. The poliovirus receptor (PVR or CD155) and its family member nectin 2 (CD112) have been identified as the ligands for DNAM1. Interaction of DNAM1 with the ligands induces NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. Since the identification of ligands for DNAM1, emerging evidence has suggested that DNAM1 also plays an important role in immune surveillance of tumor development and is involved in LFA-1-mediated costimulatory signals for triggering naive T cell differentiation and proliferation.
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