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- xy50305-R032
- 2025年07月15日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
常温，避光
- 克隆性：
单克隆
- 抗体名：
LDLR / LDL Receptor抗体
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 032
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant mouse LDLR / LDL Receptor ( rM LDLR ; Catalog #50305-M08H ; Met 1 - Arg 790 ; NP_034830.2 ).
LDLR / LDL Receptor抗体 Background
Low-density lipoprotein ( LDL ) is a type of lipoprotein that transports cholesterol and triglycerides from the liver to peripheral tissues, and enables fats and cholesterol to move within the water-based solution of the blood stream. As the prototype member of the LDLR family of scavenger receptors, the Low-Density Lipoprotein Receptor ( LDLR ) is involved in receptor-mediated endocytosis of specific ligands. LDLR recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles, as well as the apoE protein found in chylomicron remnants and VLDL remnants (IDL). In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Mouse LDLR is a mosaic protein, and the extracellular region consists of seven N-terminal complement-like cysteinerich repeats, two EGF like repeats and six class B LDL repeats that generate a β-propeller containing a YWTD motif each, and a membrane proximal Ser/Thr rich region. It is indicated that LDLR is responsible for clearing 70% of plasma LDL in liver.
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文献和实验Clonality - X Chromosome Inactivation Assay
and can assist in interpretation of allele patterns. 4. References Allen RC, Zoghbi HY, Moseley AB, Rosenblatt HM, Belmont JW. Methylation of HpaII and HhaI sites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome
Ligand- and Structure-Based Pregnane X Receptor Models
The human pregnane X receptor (PXR) is a ligand dependent transcription factor that can be activated by structurally diverse agonists including steroid hormones, bile acids, herbal drugs, and prescription medications. PXR regulates
脾细胞与小鼠骨髓瘤细胞（P3-X63/Ag8）融合，融合的细胞既获得了亲代脾细胞分泌特异性抗体的特性，又具有骨髓瘤细胞大量繁殖的能力，成为一种既能分泌特异性抗体又能长命的杂交瘤细胞。该技术为抗体的分子生物学研究提供了全新的手段。极大地促进了免疫学，遗传学，分子生物学的快速发展。 但传统抗体目前也面临诸多问题，如： 每使用一管新抗体都需要进行滴定测试； 多种同型对照，实验设计繁琐； 需要添加Fc阻断试剂； 抗体不佳，阳性细胞群不明显； 抗体作为细胞生物学和生物化学中最重要的试剂之一，科学界每年在这类
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