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- 中国/美国/德国
- xy50034-R121
- 2025年07月13日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
常温，避光
- 克隆性：
单克隆
- 抗体名：
Mouse FVII / Factor VII抗体
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 121
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant mouse FVII ( rM FVII ; Catalog#50034-M08C ; NP_034302.2 ; Met 1 - Leu 446 ).
Mouse FVII / Factor VII抗体 Background
Mouse coagulation factor VII, also known as Serum prothrombin conversion accelerator, Factor VII, F7 and FVII, is a member of the peptidase S1 family. Factor VII is one of the central proteins in the coagulation cascade. It is an enzyme of the serine protease class. Factor VII contains two EGF-like domains, one Gla (gamma-carboxy-glutamate) domain and one peptidase S1 domain. The main role of factor VII is to initiate the process of coagulation in conjunction with tissue factor ( TF ). Tissue factor is found on the outside of blood vessels, normally not exposed to the blood stream. The action of the Factor VII is impeded by tissue factor pathway inhibitor (TFPI), which is released almost immediately after initiation of coagulation. Factor VII is vitamin K dependent and is produced in the liver. The use of warfarin or similar anticoagulants impairs its function. Upon vessel injury, tissue factor is exposed to the blood and circulating Factor VII. Once bound to TF, FVII is activated to FVIIa by different proteases, among which are thrombin (factor IIa), factor Xa, IXa, XIIa, and the FVIIa-TF complex itself. The most important substrates for FVIIa-TF are Factor X and Factor IX.
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文献和实验Identification of Mutations in the Human Factor VII Gene
It has been recognized from the early 1800s that activation of coagulation can be initiated by the exposure of subendothelial layers (tissue factor), but it was the 1940s before factor VII (FVII) was included in this event
美国科学家近日通过研究，打破了一个古老的免疫学教条——一个抗体只能绑定到一个抗原上。他们成功地使一个抗体紧密地绑定到两个不同的抗原上。相关论文发表在3月20日的《科学》杂志上。 这一抗体作用于2种蛋白——血管内皮生长因子（VEGF）和人类表皮生长因子受体2（HER2），前者被认为会促进肿瘤的生长，而后者则在一些侵略性的乳腺肿瘤里高表达。 科学家以前经常发现一些抗体能够松散地绑定到多个抗原上，但一直没有发现或通过操作实现单个抗体特异性地紧密绑定到2个不同抗原上。 在此次研究中
mapping near the carboxy terminus of PEDF (pigment endothelium-derived factor) of human origin. SPECIFICITY PEDF (H-125) is recommended for the detection of PEDF (pigment endothelium-derived factor) of mouse, rat and human origin by Western blotting
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