IFNGR1 / CD119 / IFN-gamma-R1抗

The protein IFN-γR1 (IFNGR1) is the ligand-binding chain (alpha) of the high-affinity interferon gamma receptor complex which is a heterodimer of IFN-γ R1 (IFN-γ Rα) and IFN-γ R2 (IFN-γ Rβ). IFN-γ R1 is necessary and sufficient for IFN-γ binding and receptor internalization, whereas IFN-γ R2 is required for IFN-γ signal transduction, but does not bind IFN-γ by itself. IFN-γ R1 is constitutively expressed in most cell types and soluble IFN-γ R1 has been detected in biological fluids. Human IFN-γ R1 cDNA encodes a 499 aa residue protein consisting of a 17 aa signal peptide, a 228 aa extracellular domain, a 23 aa transmembrane domain, and a 221 aa intracellular domain. Upon binding to IFN-γ receptor via its C-terminus, the type II interferon IFN gamma triggers multiple intracellular signalling processes including prevention of viral replication, inhibition of cell growth, modulation of cell differentiation, and induction of growth arrest at mid-G1 in different mammary carcinoma cell lines. A genetic variation or deficiency in IFN-γR1 is associated with susceptibility to Helicobacter pylori infection or mycobacterial disease.
IFNGR1 / CD119 / IFN-gamma-R1抗体相关产品如下：xy-12420R 14-3-3 beta14-3-3β抗体
xy-2682R SLAMF6SLAMF6抗体
xy-2675R SPECAa-包衬蛋白抗体
xy-4025R phospho-Syntaxin 1a(Ser14)磷酸化突触融合蛋白1抗体
xy-4038R SLC25A13线粒体内钙结合天冬氨酸/谷氨酸载体蛋白抗体
xy-4037R SLC25A11线粒体二羧酸载体蛋白11抗体
xy-3839R 4EBP2eIF4E结合蛋白2抗体
xy-3765R Serum Amyloid P血清淀粉样蛋白P成份抗体
xy-11423R Sox3转录因子Sox3抗体
xy-11425R Secretogranin V神经内分泌颗粒蛋白5抗体
xy-11399R Synaptotagmin XI突触结合蛋白11抗体
xy-11436R SLCO1C1溶质载体家族蛋白21成员1C1抗体
xy-6881R SCN3B电压门控钠通道SCN3B蛋白抗体
xy-11396R rSec6胞吐分泌蛋白Sec6抗体
xy-11378R Syntaxin 13神经突触素13抗体
xy-11380R Syntenin 2多配体聚糖结合蛋白2抗体
xy-6397R SCGB3A1结合珠蛋白家族3A1抗体
xy-6111R SSBP2抑癌基因SSDP2抗体
xy-5459R phospho-Smad3 (Ser213)磷酸化细胞信号转导分子SMAD3抗体
xy-6282R SERPINB4丝氨酸蛋白酶抑制剂B4抗体(鳞状细胞癌抗原)
xy-4217R Sphingomyelin Synthase 2鞘磷脂合成酶2抗体
xy-4218R Squalene Epoxidase鲨烯环氧酶抗体
xy-6283R SULT1A1芳基磺基转移酶1抗体
xy-2916R SPINK1/SPINK3肿瘤相关胰蛋白酶抑制剂1抗体
xy-5818R Sulfatase 1硫酸酯酶1抗体
xy-7536R SERPINA12内脏脂肪组织源性丝氨酸蛋白酶抑制蛋白抗体
xy-7537R SIRT4沉默调节相关蛋白4抗体
xy-7539R SERCA1 ATPase肌浆网钙ATP酶1/内质网钙ATP酶1抗体
xy-2917R SPINK1肿瘤相关胰蛋白酶抑制剂1抗体
xy-6997R SAP62剪接体相关蛋白62抗体
xy-9764R phospho-Stathmin 1 (Ser63)磷酸化原癌基因蛋白18抗体
xy-9765R phospho-Stathmin 1 (Ser24)磷酸化原癌基因蛋白18抗体
xy-9190R SLFN14Schlafen家族14抗体
xy-9191R SEMCAP3SEMCAP3蛋白抗体
xy-9012R SENP1小泛素相关修饰蛋白1抗体