CD50 / ICAM-3抗体

CD50 / ICAM-3抗体产品信息免疫原 : Recombinant Human CD50 / ICAM-3 protein (Catalog#10333-H08H)

Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 101

抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Human CD50 / ICAM-3 (rh CD50 / ICAM-3; Catalog#10333-H08H; NP_002153.2; Met 1-His 485).
CD50 / ICAM-3抗体 Background
The protein ICAM3, also known as CD50, is a member of the intercellular adhesion molecule (ICAM) family consisting three members. All ICAM proteins are type I transmembrane glycoproteins, and are ligands for leukocyte function-associated antigen 1 (LFA-1) expressed on the surface of all white blood cells. ICAM-3 comprises of five immunoglobulin-like domains, and binds LFA-1 through its two N-terminal domains. It functions not only as an adhesion molecule, but also as a potent signalling molecule.ICAM3 is constitutively and abundantly expressed by all leucocytes, and thus is the major ligand for LFA-1 in the initiation of primary immune responses. It has been reported that CD50 molecule can play a role in developing functionally mature T lymphocytes and its expression increases during the maturation process of T lymphocytes. In addition, the interactions of ICAM-3 and LFA-1 facilitate HIV-1- induced virological synapse formation between T cells.
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