ADAM15 / MDC15抗体

The adamalysin (ADAM) metalloproteinase disintegrins, also known as metalloprotease / disintegrin/cysteine-rich proteins, are a branch of the metzincin metalloproteinase superfamily that are related to snake venom metalloproteinases and integrin ligands. Human ADAM15 was first named metargidin, and uniquely, it carries an RGD binding motif in a position similar to that in snake venom disintegrins. ADAM15 is widely expressed in various tissues and cells, including human umbilical vein endothelial cells and smooth muscle cells, and its expression can be drived by Vascular endothelial (VE)-cadherin. Overexpression of ADAM15 in NIH3T3 cells appears to enhance cell-cell interactions, as suggested by decreased cell migration, altered cell morphology at the wound edge, decreased monolayer permeability, and increased cell adhesion to monolayers of cells expressing ADAM15 by retroviral transduction. ADAM15 plays a physiological role as a natural binding partner of integrin αvβ3 thereby loosening tumor cell adhesion to the underlying matrix and regulating tumor cell migration and invasion, and functional interplay between ADAM15 and Src family PTKs may contribute to signaling in hematopoietic cells. Aslo, ADAM15 is believed to interact with integrins αvβ3, α5β1, and α9β1 through its disintegrin domain. ADAM15 has been shown to degrade collagens I and IV and to cleave the inflammatory cytokine CD23, thus influence ECM remodeling within rheumatoid synovial tissues and in atherosclerosis.
ADAM15 / MDC15抗体相关产品如下：xy-0197xy PACAP/VIP receptor腺苷酸环化酶激活肽/血管活性肠肽受体（抗原）
xy-0198xy PACAP receptor-I腺苷酸环化酶激活肽受体（抗原）
xy-0318xy PADI4 (HL-60 PAD)(Protein-arginine deiminase type IV，PADI 4，PAD I4 )关节炎相关基因
xy-0196xy PDGF-A血小板源性生长因子-1（抗原）
xy-0185xy PDGF-B血小板源性生长因子-B（抗原）
xy-0231xy PDGF-R-A血小板源性生长因子受体-A（抗原）
xy-0232xy PDGF-R-B血小板源性生长因子受体-B（抗原）
xy-0235xy PMP-22(Peripheral Myelin Protein)外周髓鞘蛋白-22多肽
xy-0128xy PI3K磷脂酰肌醇激酶（抗原）
xy-1374xy BMP4(bone morphogenetic protein 4)骨形态发生蛋白4（抗原）
xy-0234xy PLGF (Placenta growth factor)小鼠胎盘生长因子（多肽抗原）
xy-0280xy PLGF (Placenta growth factor)胎盘生长因子（多肽抗原）
xy-0281xy PLGF (Placenta growth factor fragment)(human)人胎盘生长因子（多肽抗原）
xy-0133xy PP-1蛋白磷酸酯酶-1（抗原）
xy-1509xy BMPR-1A(Bone Morphogenetic protein Receptor-1A)骨成型蛋白受体1A抗原
xy-0250xy PPAR-delta (peroxisome proliferator-activated receptor)D型-过氧化酶活化增生受体(多肽）
xy-0029xy PP-2A (protein phosphatase 2A)蛋白质磷酸酶-2A（抗原）
xy-1418xy BOb-1(B-cell oct-binding protein 1)B细胞特异性转录因子抗原
xy-0030xy PP-2B alpha 1 蛋白磷酸酯酶-2B 催化亚单位（抗原）
xy-0111xy PR (Progestogerone receptor)孕激素受体（抗原）
xy-0024xy PS-1(NT)，Presennillin-1(S182)早老素蛋白-1（抗原）
xy-0025xy PS-1，Presennillin-1(CT)早老素蛋白-1（S182）
xy-0803xy BRCA1(Breast cancer susceptbility gene 1)(mouse rat)乳腺癌易感基因1抗原(小鼠 大鼠)
xy-0802xy BRCA1乳腺癌易感基因1抗原
xy-0179xy PSD-95 突触后密度蛋白95（抗原）
xy-1210xy BRCA2(Breast cancer susceptbility gene 2)乳腺癌易感基因2抗原
xy-0182xy PTP-1B (Protein-tyrosine phosphatase, non-receptor )蛋白酪氨酸磷酸酶-1B（抗原）
xy-0251xy RAR-Alpha (Retinoic acid -R-Alpha)维甲酸受体-α 多肽
xy-0319xy glycoprotein (E1 glycoprotein) [Rubella virus]风疹病毒糖蛋白多肽片段
xy-0121xy SAP-1 (Synapse associated protein-I) peptide突触相关蛋白-1（多肽抗原）
xy-0130xy SARS S-protein(抗原)
xy-0132xy SARS putative orflab polyprotein (SARS coronavirus CUHK-W1)(抗原)
xy-1954xy BSEP peptide胆汁酸盐输出泵蛋白抗原
xy-0088xy Secretin分泌素（抗原）
xy-0089xy Secretin receptor分泌素受体（抗原）