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视黄酸信号PCR芯片 Retinoic Acid Signa

ling PCR Array
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  • Retinoic Acid Signaling PCR Array
  • 2026年01月23日
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    上海英拜生物科技有限公司
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    • 服务名称：

      PCR芯片

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      qiagen

    The Human Retinoic Acid Pathway RT² Profiler PCR Array profiles the expression of 84 key genes involved in retinoic acid signaling. Retinoic acid (RA) is the primary functional derivative of vitamin A (retinol) and its activity is implicated in many aspects of vertebrate development and homeostasis, while disruptions in this pathway cause developmental abnormalities and disrupt function in adipose, cardiac, nervous, reproductive, and integumentary tissues, among others. RA acts primarily by binding a family of nuclear receptors (the retinoic acid receptors alpha, beta, and gamma) that then heterodimerize with their partners (the retinoid X receptors alpha, beta, and gamma) and alter transcription. Additionally, recent evidence suggests that an alternative receptor (PPAR delta) also responds to RA signaling in some tissues and that retinol, and RA may also induce non-genomic cellular effects. Thus, the effect of RA depends on the expression of its cognate receptors, enzymes responsible for converting retinol to RA, metabolic enzymes that reduce RA levels, and transport proteins, some of which act as signal transducers that appear to influence the distribution of RA and its metabolic precursors. This array includes genes encoding the known receptors and proteins responsible for synthesis, transport and metabolism of RA and its precursors, as well as downstream targets of RA signaling. Results obtained with this array can yield insights into RA signaling mechanisms and responses. A set of controls present on each array enables data analysis using the ΔΔCT method of relative quantification and assessment of reverse transcription performance, genomic DNA contamination, and PCR performance. Using real-time PCR, research studies can easily and reliably analyze the expression of a focused panel of genes involved in retinoic acid signaling with this array.

    The RT² Profiler PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.

    96-well Plate, 384-well (4 × 96) Plate, and 100-well Disc formats are available.
    Available for cells, tissues, FFPE samples and small samples

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    • 调节睡眠的视黄酸信号

      ）还不清楚。Maret 等人在小鼠中的研究表明，编码视黄酸受体β（etinoic acid receptor beta）的基因决定了δ震荡对睡眠的脑电图的影响。因此，参与大脑和多巴胺通路（dopaminergic pathways）图示发育（patterning）的视黄酸信号调节了成人皮质的综合症状（cortical synchrony）。     图：Mapping of a gene regulating the relative

    • Detection and Measurement of Retinoic Acid Production by Isolated Tissues Using Retinoic Acid-Sensitive Reporter Cell Lines

      Retinoids are diffusible signaling molecules important for the normal development, growth, and physiology of vertebrate organisms A role for retinoids in early embryonic development has been suggested from studies in which exogenous retinoids

    • PCR Array 简单实用的检测基因表达的高通量方法

      提供的PCR Array产品举例 订制的PCR芯片 如果现有的产品无法满足研究者的特定需要，SuperArray还可以提供从设计到芯片生产的完整服务，为研究者提供使用先进的PCR芯片的便捷服务。客户订制芯片服务为研究者提供以下便利：1）在使用表达谱基因组芯片后，对从基因组水平筛选出来的一组基因进行验证；2）在现有产品的基础上作适当调整以适应特殊需要；3）完全从头设计，适用于在现有的预设计PCR芯片中尚未包括的某个信号通路或者一组基因。若研究基因数目少于84个，还可以将96孔PCR芯片进一步分成

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